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| Immunogen | Recombinant Mouse CD80 / B7-1 protein (Catalog#50446-M08H) |
| Antibody Type | Rabbit Polyclonal Antibody ( Antibody Purification Platform ) |
| Ig Type | Rabbit IgG |
| Formulation | 0.2 μm filtered solution in PBS with 5% trehalose |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse CD80 / B7-1 (rM CD80 / B7-1; Catalog#50446-M08H; Q00609-1; Met 1-Lys 245). Total IgG was purified by Protein A affinity chromatography. |
| Specificity | Mouse CD80 / B7-1 |
| Western blot | This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human CD80 in WB. |
| Direct ELISA | This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human CD80. The detection limit for Human CD80 is approximately 0.039 ng/well. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CD80/B7-1
Immunology>>Adaptive Immunity>>T Cell>>T Cell Antigen Recognition>>CD80/B7-1
Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD80/B7-1
Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Co-stimulatory Molecules>> CD80/B7-1
Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers>> CD80/B7-1
Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>T Cell Antigen Recognition>>CD80/B7-1
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| CD80/B7-1 | Human | CD80/B7-1/Fc Protein, Recombinant | 10698-H03H |
| CD80/B7-1 | Human | CD80/B7-1 Protein, Recombinant | 10698-H08H |
| CD80/B7-1 | Human | CD80/B7-1 Protein, Recombinant | 10698-HCCH |
| CD80/B7-1 | Mouse | CD80/B7-1 Protein, Recombinant | 50446-M08H |
| CD80/B7-1 | Mouse | CD80 / B7-1 Protein, Recombinant | 50446-M02H |
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human CD80/B7-1 | WB, ELISA | CD80 / B7-1 Antibody | 10698-RP01 |
| Human CD80/B7-1 | WB, ELISA | CD80 / B7-1 Antibody (Antigen Affinity Purified) | 10698-RP02 |
| Human CD80/B7-1 | WB, ELISA | CD80 / B7-1 Antibody | 10698-MM01 |
| Human CD80/B7-1 | FCM | CD80 / B7-1 Antibody ( FITC ) | 10698-MM01-F |
| Mouse CD80/B7-1 | WB, ELISA | CD80 / B7-1 Antibody | 50446-RP01 |
| Mouse CD80/B7-1 | WB, ELISA | CD80 / B7-1 Antibody (Antigen Affinity Purified) | 50446-RP02 |
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. Binding of this protein with CTLA-4 is involved in down-regulation of immune response.Recent study has revealed that contacts between B and T helper cells mediated by CD80 provide negative signal for the proliferation and IgG secretion of normal B cells and B cell lymphomas. In addition, B7-1 also plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages.CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
Sino Biological Inc. liefert CD80 / B7-1 Antikkörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.
Weitere Informationen über CD80 / B7-1 Antikkörper lesen Sie bitte: http:www.sinobiological.com/CD80-B7-1-Antibody-g-9253.html
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