CD27 Antikörper

21.06.2012

Produkt-Information von CD27 Antikörper

Immunogen	Recombinant Human CD27 protein (Catalog#10039-H03H)
Antibody Type	Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
Clone ID	1C6D1
Ig Type	Mouse IgG1
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD27 (rh CD27; Catalog#10039-H03H; NP_001233.1; Met 1-Ile 192). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Usage Guide von CD27 Antikörper

Specificity	Human CD27
	No cross-reactivity in ELISA with Human cell lysate (293 cell line)
Direct ELISA	This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human CD27. The detection limit for Human CD27 is approximately 0.078 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Related Areas:

Cancer>>Cancer Stem Cell (CSC)>>CD27/TNFRSF7

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CD27/TNFRSF7

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>CD27/TNFRSF7

Immunology>>Cytokine & Receptor>>TNF Superfamily>>CD27/TNFRSF7

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD27/TNFRSF7

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>CD27/TNFRSF7

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>CD27/TNFRSF7

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Regulatory T Cells>>CD27/TNFRSF7

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD27	Human	CD27/Fc Protein, Recombinant	10039-H03H
CD27	Mouse	CD27/Fc Protein, Recombinant	50110-M03H
CD27	Mouse	CD27 Protein, Recombinant	50110-M08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD27	WB, ELISA	CD27 Antibody	10039-MM08
Human CD27	WB, ELISA	CD27 / TNFRSF7 Antibody ( FITC )	10039-R023F
Human CD27	WB, ELISA	CD27 / TNFRSF7 Antibody ( PE )	10039-R023-P
Human CD27	WB, ELISA	CD27 / TNFRSF7 Antibody ( FITC )	10039-R025F
Human CD27	WB, ELISA	CD27 Antibody	10039-R036
Mouse CD27	WB, ELISA	CD27 Antibody, Rabbit PAb	50110-RP01
Mouse CD27	WB, ELISA	CD27 Antibody, Rabbit PAb (Antigen Affinity Purified)	50110-RP02
Mouse CD27	FCM	CD27 / TNFRSF7 Antibody ( FITC )	50110-R012-F
Mouse CD27	WB, ELISA	CD27 Antibody	50110-R034
Mouse CD27	WB ELISA	CD27 Antibody	50110-R133

Hintergrund von CD27 Antikörper

CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis. The CD27 receptor transduces signals and subsequently leads to the activation of NF-kappaB and MAPK8/JNK, and during which, adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling processes. In addition, a proapoptotic protein named SIVA, is capable of binding the cytoplasmic tail of CD27 and exerts action in the process of apoptosis.

References

Borst. J. et al., 2005, Curr. Opin. Immunol. 17: 275-281.
Kobata. T. et al., 1995, Proc. Natl. Acad. Sci. 92: 11249-53.
Jacquot, S., 2000, Immunol Res. 21:23-30.
Arens, R. et al., 2004, J. Immunol. 173: 3901-3908.
Akiba, H. et al., 1998, J. Biol. Chem. 273: 13353-13358.
Fortin, A. et al., 2004, J. Biol. Chem. 279: 28706-28714.

Sino Biological Inc. liefert CD27 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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