CD200RLa / CD200R1L Antikörper

26.06.2012

Produkt-Information von CD200RLa / CD200R1L Antikörper

Immunogen	Recombinant Human CD200RLa / CD200R1L protein (Catalog#11620-H08H)
Antibody Type	Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
Clone ID	6D6C1
Ig Type	Mouse IgG1
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD200RLa / CD200R1L (rh CD200RLa / CD200R1L; Catalog#11620-H08H; NP_001008784.2; Met 1-Leu 239, one aa mutation 113Arg /Leu ). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Usage Guide von CD200RLa / CD200R1L Antikörper

Specificity	Human CD200RLa / CD200R1L
	No cross-reactivity in ELISA with Human cell lysate (293 cell line)
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human CD200R1L in WB. Using a DAB detection system, the detection limit for Human CD200R1L is approximately 1 ng/lane under non-reducing conditions and 2 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human CD200R1L. The detection limit for Human CD200R1L is approximately 0.039 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von CD200RLa / CD200R1L Antikörper

Related Areas:

Immunology>>Cluster of Differentiation>>Other>>CD200R4

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD200RLa	Human	CD200RLa/CD200R1L Protein, Recombinant	11620-H08H
CD200RLa	Mouse	CD200R4 / CD200 Receptor 4 / CD200RLa Protein, Recombinant	50639-M02H
CD200RLa	Mouse	CD200R4 / CD200 Receptor 4 / CD200RLa Protein, Recombinant	50639-M08H
CD200RLa	Cynomolgus	CD200RLa/Fc Protein, Recombinant	11576-C02H
CD200RLa	Cynomolgus	CD200RLa Protein, Recombinant	11576-C08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD200RLa	WB, ELISA	CD200RLa Antibody, Rabbit MAb	11620-R111
Human CD200RLa	WB, ELISA	CD200RLa / CD200R1L Antibody	11620-RP01
Human CD200RLa	WB, ELISA	CD200RLa / CD200R1L Antibody (Antigen Affinity Purified)	11620-RP02
Human CD200RLa	WB, ELISA	CD200RLa Antibody	11620-MM05
Human CD200RLa	WB, ELISA	CD200RLa / CD200R1L Antibody	11620-MM09
Mouse CD200RLa	WB, ELISA	CD200R4 / CD200RLa Antibody	50639-RP01
Mouse CD200RLa	WB, ELISA	CD200R4 / CD200RLa Antibody (Antigen Affinity Purified)	50639-RP02
Cynomolgus CD200RLa	WB, ELISA	CD200RLa Antibody, Rabbit MAb	11576-R015
Cynomolgus CD200RLa	WB, ELISA	CD200RLa Antibody, Rabbit PAb	11576-RP01
Cynomolgus CD200RLa	WB, ELISA	CD200RLa Antibody, Rabbit PAb (Antigen Affinity Purified)	11576-RP02

Hintergrund von CD200RLa / CD200R1L Antikörper

Cell surface glycoprotein CD200 receptor 2, also known as Cell surface glycoprotein CD200 receptor 1-like, Cell surface glycoprotein OX2 receptor 2, CD200 receptor-like 2, CD200Rla, CD200R1L and CD200R2, is a single-pass type I membrane protein which belongs to theCD200R family. CD200R1L / CD200R2. It contains oneIg-like C2-type (immunoglobulin-like) domain and oneIg-like V-type (immunoglobulin-like) domain. CD200 is a transmembrane protein delivering immunoregulatory signals after engagement of CD200R. A family of CD200Rs exist (CD200R1, CD200R2, CD200R3, CD200R4) with different tissue expression and functional activity. In the presence of anti-CD200R2 / CD200R3 monoclonal antibodies (mAbs), bone-marrow cells cultured in the presence of (interleukin [IL]-4+granulocyte-macrophage colony-stimulating factor) differentiate into dendritic cells (DCs), which induce CD4+CD25+ Treg. Interaction between the relatively ubiquitously expressed molecule CD200 and one of its receptors, CD200R1, resulted in direct suppression of alloreactivity, engagement of alternate receptors led instead to altered differentiation of dendritic cells (DCs) from marrow precursors, which could in turn foster development of Foxp3 (+) regulatory T cells. Unlike anti-CD200R1, anti-CD200R2 both promotes development of DCs with capacity to induce Treg and directly augments thymocyte production of Treg.

References

Wright G.J.et al., 2003, J. Immunol. 171: 3034-46.
Gorczynski R.M.et al. 2004, Am. J. Reprod. Immunol. 52: 147-63.
Muzny D.M. et al., 2006, Nature. 440: 1194-8.

Sino Biological Inc. liefert CD200RLa / CD200R1L Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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