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| Immunogen | Recombinant Human BID protein (Catalog#10468-HNCE) |
| Antibody Type | Mouse Monoclonal Antibody ( Mouse mAb Service Platform ) |
| Clone ID | 3C4C2 |
| Ig Type | Mouse IgG2a |
| Formulation | 0.2 μm filtered solution in PBS with 5% trehalose |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human BID (rh BID; Catalog#10468-HNCE; P55957-1; Met 1-Asp 195). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Specificity | Human BID |
| No cross-reactivity in ELISA with E.coli cell lysate | |
| Western blot | This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human BID in WB. Using a DAB detection system, the detection limit for Human BID is approximately 8 ng/lane under non-reducing conditions and 2 ng/lane under reducing conditions. |
| Direct ELISA | This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human BID. The detection limit for Human BID is approximately 0.078 ng/well. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
Cancer>>Apoptosis>>Bcl-2 Family>>BID
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| BID | Human | BID Protein, Recombinant | 10468-HNCE |
| BID | Mouse | BID Protein, Recombinant, with GST Tag | 50351-M20E |
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human BID | WB,ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) | 10468-RP02 |
| Human BID | WB,ELISA | BID Antibody | 10468-MM02 |
| Human BID | WB,ELISA | BID Antibody ( FITC ) | 10468-MM10-F |
BID, BH3-interacting domain death agonist, is a member of the Bcl-2 protein family. BID contains only the BH3 domain, which is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. BID is susceptible to proteolytic cleavage by caspases, calpains, Granzyme B and cathepsins. It is an integrating key regulator of the intrinsic death pathway that amplifies caspase-dependent and caspase-independent execution of neuronal apoptosis. Therefore pharmacological inhibition of BID provides a promising therapeutic strategy in neurological diseases where programmed cell death is prominent, and also offer a new strategy for the treatment of acute renal failure associated with ischemia-reperfusion. BID receives direct inputs from a key regulator of the cell cycle arrest/DNA repair machinery (ATM), and therefore is an excellent candidate to coordinate genotoxic stress responses and apoptotic cell death. BID is a novel pro-apoptosis Bcl-2 family protein that is activated by caspase 8 in response to Fas/TNF-R1 death receptor signals. Activated BID is translocated to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. Recent studies further indicate that BID may be more than just a killer molecule. Deletion of BID inhibits carcinogenesis in the liver, although this genetic alteration promotes tumorigenesis in the myeloid cells. This is likely related to the function of BID to promote cell cycle progression into S phase. BID could be also involved in the maintenance of genomic stability by engaging at mitosis checkpoint.
Sino Biological Inc. liefert BID Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.
Weitere Informationen über BID Antikörper lesen Sie bitte: http://www.sinobiological.com/BID-Antibody-g-9094.html
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