CD155 / PVR Antikörper ( FITC )

Produkt-Information von CD155 / PVR Antikörper

Usage Guide von CD155 / PVR Antikörper

Specificity	Human CD155 / PVR
Flow Cytometry	Flow cytometric analysis of CD155 reactivity on HeLa cells. Profile of CD155 reactivity on HeLa cells analyzed by flow cytometry. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃- 8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Verwandte Produkte & Themen von CD155 / PVR Antikörper

Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>CD155

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers / Monocyte Markers>>CD155

Hintergrund von CD155 / PVR Antikörper

CD155, also known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily of immunoglobulin superfamily. This protein contains three Ig-like extracellular domains, a transmembrane segment, and a cytoplasmic tail. In humans, CD155 is predominately expressed by enterocytes and cells of gastrointestinal lymphatic tissues and originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function of CD155 maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the CD155 mRNA yields four different isoforms (α, β, γ, and δ) with the identical extracellular domains. CD155-β and-γ are secreted, whereas the membrane-bound CD155-α and -δ serve as PV receptors. In addition, it has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.

References

1. Mendelsohn, C.L. et al., 1989, Cell. 56: 855-865.
2. He,Y. et al., 2000, Proc. Natl. Acad. Sci. U.S.A. 97: 79-84.
3. Simon, K. et al., 2001, J. Virol. 75: 4984-4989.
4. Minami,Y., et al., 2007, J. Biol. Chem. 282: 18481-18496.
5. Fuchs, A. et al., 2004, J. Immunol. 172: 3994-3998.
6. Tahara-Hanaoka,S. et al., 2006, Blood. 107: 1491-1496.

Sino Biological Inc. liefert CD155 / PVR Antikörper ( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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