CD14 Protein (His Tag)

Produkt-Information von CD14 Protein

QC Testing von CD14 Protein

Purity	> 97 % as determined by SDS-PAGE	SDS-PAGE: CD14 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Thr 20
Molecular Mass	The secreted recombinant human CD14 consists of 336 amino acids and has a predicted molecular mass of 36.5 kDa. The apparent molecular mass of rhCD14 is approximately 45 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from 0.2μm filtered solutionof PBS, pH7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

CD14 Protein Usage Guide

Verwandte Produkte & Themen von CD14 Protein

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Lineage Markers>>CD14

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Monocyte Markers>>CD14

Beschreibung von CD14 Protein

CD14 is a myelomonocytic differentiation antigen preferentially expressed on monocytes, macrophages, and activated granulocytes. CD14 exists as two forms, either anchored into the membrane by a GPI-anchor tail (mCD14) or present as a soluble form (sCD14) in normal serum and body fluids. CD14 was first described as a pattern recognition receptor for lipopolysaccharide (LPS) and a variety of ligands derived from different microbial sources, along with the co-receptors Toll-like receptor TLR 4 and MD-2. The binding of CD14 and LPS depends on the presence and catalytic activity of lipopolysaccharide-binding protein (LBP). Besides its endotoxin signaling function, CD14 has been proposed to be involved in various biological processes, including transportation of other lipids, cell-cell interaction during different immune responses, as well as recognition of apoptotic cells. Multiple transcript variants resulting from alternative splicing encode the same isoform of CD14.

References

1. Simmons, D.L. et al., 1989, Blood. 73: 284-289.
2. Goyert, S.M. et al., 1988, Science. 239: 497-500.
3. Heidenreich, S. et al., 1999, J. Leukoc. Biol. 65: 737-743.
4. Power, C.P. et al., 2004, J. Immunol. 173: 5229-5237.
5. Asea, A. et al., 2000, Nat. Med. 6: 435-442.

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