CD13 / ANPEP Antikörper

11.05.2012

Produkt-Information von CD13 / ANPEP Antikörper

Immunogen	Recombinant Human CD13 / ANPEP protein (Catalog#10051-H08H)
Antibody Type	Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
Clone ID	122
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was obtained from a rabbit immunized with purified, recombinant Human CD13 / ANPEP (rh CD13 / ANPEP; Catalog#10051-H08H; NP_001141.2; Lys 69-Lys 967, 603 Met/Ile).

Usage Guide von CD13 / ANPEP Antikörper

Specificity

Human CD13 / ANPEP

Immunochemistry

IHC-P: 1-10 μg/mL

ANPEP-liver immunohistochemistry ANPEP-renal-carcinoma immunohistochemistry

Immunochemical staining of human ANPEP in human liver with rabbit monoclonal antibody (5 μg/mL, formalin-fixed paraffin embedded sections).

Immunochemical staining of human ANPEP in human renal carcinoma with rabbit monoclonal antibody (5 μg/mL, formalin-fixed paraffin embedded sections).

Western blot

This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human ANPEP in WB.

Direct ELISA

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human ANPEP.

Storage

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃.Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von CD13 / ANPEP Antikörper

Related Areas:

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>CD13/ANPEP

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Granulocyte Markers>>CD13/ANPEP

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Monocyte Markers>>CD13/ANPEP

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD13/ANPEP	Human	CD13/ANPEP Protein, Recombinant	10051-H08H
CD13/ANPEP	Mouse	CD13/ANPEP Protein, Recombinant	50001-M08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD13/ANPEP	WB, ELISA	CD13/ANPEP Antibody, Rabbit PAb	10051-RP01
Human CD13/ANPEP	WB, ELISA, IHC-P	CD13/ANPEP Antibody, Rabbit PAb (Antigen Affinity Purified)	10051-RP02
Human CD13/ANPEP	WB, ELISA, IHC-P	CD13 / ANPEP Antibody	10051-R122
Human CD13/ANPEP	WB, ELISA	Rabbit Monoclonal Antibody	10051-R123
Mouse CD13/ANPEP	WB, ELISA, IHC-P	CD13/ANPEP Antibody, Rabbit MAb	50001-R101
Mouse CD13/ANPEP	ELISA	Rabbit Polyclonal Antibody	50001-RP01
Mouse CD13/ANPEP	WB, ELISA	Rabbit Polyclonal Antibody	50001-RP02

Hintergrund von CD13 / ANPEP Antikörper

Aminopeptidase N (APN, ANPEP), also known as CD13, is a cell-surface metalloprotease located in the small-intestinal and renal microvillar membrane, as well as other plasma membranes. CD13/ANPEP plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases and is involved in the metabolism of regulatory peptides by diverse cell types. CD13/ANPEP is a potent regulator of angiogenesis which is essential for tumor invasion and metastasis, and its transcription in activated endothelial cells is induced by angiogenic growth factors via the RAS/MAPK pathway. In addition, this enzyme has been shown to participate in antigen processing and presentation, and accordingly, defects in this gene appear to be a cause of various types of leukemia or lymphoma and carcinomas. Furthermore, human CD13/ANPEP is a receptor for one strain of human coronavirus strain HCV-229E that is an important cause of upper respiratory tract infections.

References

Falk, K. et al., 1994, Immuno genetics. 39: 230-242.
Petrovic, N. et al., 2003, J. Biol. Chem. 278: 49358-49368.
Yeager, C.L. et al., 1992, Nature. 357: 420-422.
Bhagwat, S.V. et al., 2003, Blood. 101: 1818-1826.
Pasqualini, R. et al., 2000, Cancer Res. 60: 722-727.

Sino Biological Inc. liefert CD13 / ANPEP Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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