CANT1 Protein (His Tag)

28.03.2012

Produkt-Information von CANT1 Protein

Synonym	DBQD, SCAN-1, SCAN1, SHAPY
Protein Construction	A DNA sequence encoding the human CANT1 (Q8WVQ1-1) extracellular domain (Gly 80-Ile 401) was fused with polyhistidine tag at the N-terminus.
Source	Human
Expression Host	Human Cells

CANT1 Protein QC Testing

Purity	> 88 % as determined by SDS-PAGE	SDS-PAGE: CANT1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human CANT1 consists of 342 amino acids and has a calculated molecular mass of 38 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh CANT1 is approximately 40kDa.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

CANT1 Protein Usage Guide

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von CANT1 Protein

CANT1(calcium activated nucleotidase 1, N-Histidine-tagged) belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Alternatively spliced transcript variants have been noted for this gene. Defects in CANT1 are the cause of desbuquois dysplasia. A chondrodysplasia characterized by severe prenatal and postnatal growth retardation (less than -5 SD), joint laxity, short extremities, progressive scoliosis, round face, midface hypoplasia, prominent bulging eyes. The main radiologic features are short long bones with metaphyseal splay, a 'Swedish key' appearance of the proximal femur (exaggerated trochanter), and advance carpal and tarsal bone age. Two forms of desbuquois dysplasia are distinguished on the basis of the presence (type 1) or absence (type 2) of characteristic hand anomalies: an extra ossification center distal to the second metacarpal, delta phalanx, bifid distal thumb phalanx, and phalangeal dislocations.

References

Failer BU. et al., 200, J Biol Chem. 277 (40): 36978-86.
Smith TM et al., 2002, Arch Biochem Biophys. 406 (1): 105-15.
Strausberg RL. et al., 2003, Proc Natl Acad Sci. 99 (26): 16899-903.

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