C7 / Complement component 7 Protein (His Tag)

10.09.2012

Produkt-Information von C7 / Complement component 7 Protein

Synonym	C7
Protein Construction	A DNA sequence encoding the human C7 (P10643)(Met1-Gln843 )with a C-terminal polyhistidine tag was expressed.
Source	Human
Expression Host	Human Cells

C7 / Complement component 7 Protein QC Testing

Purity	> 88 % as determined by SDS-PAGE	SDS-PAGE: C7 / Complement component 7 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ser 23
Molecular Mass	The recombinant human C7 comprises 832 amino acids and has a predicted molecular mass of 92.6 kDa. The apparent molecular mass of the protein is approximately 92-98 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von C7 / Complement component 7 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von C7 / Complement component 7 Protein

Complement component 7 is a member of the complement C6/C7/C8/C9 family. It contains 1 EGF-like domain, 1 LDL-receptor class A domain, 1 MACPF domain, 2 Sushi (CCP/SCR) domains and 2 TSP type-1 domains. As a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. As a constituent of MAC, it plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Complement component 7 serves as a membrane anchor. Defects in C7 are a cause of complement component 7 deficiency (C7D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.

References

Bossi F. et al., 2009, Blood. 113 (15): 3640-8.
Kuijpers TW. et al., 2010, Mol Immunol. 47 (4): 671-7.
Thomas AD. et al., 2012, Mol Immunol. 50 (1-2): 57-9.

Sino Biological Inc. liefert C7 / Complement component 7 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über C7 / Complement component 7 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/C7-Complement-component-7-Protein-g-9238.html

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
Complement component 7	Human	C7 / Complement component 7 Protein, Recombinant	13848-H02H
Complement component 7	Human	C7 / Complement component 7 Protein, Recombinant	13848-H08H