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Sino Biological Inc. liefert BLVRB / biliverdin reductase B Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.
Weitere Informationen über BLVRB / biliverdin reductase B Antikörper lesen Sie bitte: http://www.sinobiological.com/BLVRB-biliverdin-reductase-B-Antibody-g-10142.html
| Immunogen | Recombinant Human BLVRB / biliverdin reductase B protein (Catalog#13151-H07E) |
| Antibody Type | Mouse Monoclonal Antibody ( Mouse mAb Service Platform ) |
| Clone ID | 02 |
| Ig Type | Mouse IgG2b |
| Formulation | 0.2 μm filtered solution in PBS with 5% trehalose |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human BLVRB / biliverdin reductase B (rh BLVRB / biliverdin reductase B; Catalog#13151-H07E; P30043; Ala 2-Gln 206). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Specificity | Human BLVRB / biliverdin reductase B |
| No cross-reactivity in ELISA with E.coli cell lysate | |
| Direct ELISA | This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human BLVRB. The detection limit for Human BLVRB is approximately 0.078 ng/well. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
Enzyme >>Protease & Regulator >>Serine Protease & Regulator >>Serpin Superfamily >>BLVRB
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| BLVRB | Human | BLVRB / biliverdin reductase B Protein, Recombinant | 13151-H07E |
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human BLVRB | ELISA | BLVRB / biliverdin reductase B Antibody | 13151-MM02 |
Biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin. BVR consists of an N-terminal dinucleotide-binding domain (Rossmann-fold) and a C-terminal domain that contains a six-stranded β-sheet that is flanked on one face by several α-helices. The C-terminal and N-terminal domains interact extensively, forming the active site cleft at their interface. Biliverdin reductase (BVR) catalyzes the last step in heme degradation by reducing the γ-methene bridge of the open tetrapyrrole, biliverdin IXα, to bilirubin with the concomitant oxidation of a β-nicotinamide adenine dinucleotide (NADH) or β-nicotinamide adenine dinucleotide phosphate (NADPH) cofactor. It is now recognized that human BVR (hBVR) is a dual-specificity kinase (Ser/Thr and Tyr) upstream activator of the insulin/insulin growth factor-1 (IGF-1) and mitogen-activated protein kinase (MAPK) signaling pathways. Human BVR (hBVR) is essential for MAPK-extracellular signal-regulated kinase (ERK)1/2 (MEK)-eukaryotic-like protein kinase (Elk) signaling and has been identified as the cytoplasm-nuclear heme transporter of ERK1/2 and hematin, the key components of stress-responsive gene expression.
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