B7S1 / VTCN1 / B7-H4 Protein

Sino Biological Inc. liefert B7S1 / VTCN1 / B7-H4 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Produkt-Information von B7S1 / VTCN1 / B7-H4 Protein

QC Testing von B7S1 / VTCN1 / B7-H4 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: B7S1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Phe 29
Molecular Mass	The recombinant human VTCN1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 471 amino acids and has a predicted molecular mass of 52.3 kDa. The apparent molecular mass of the protein is approximately 66-76 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von B7S1 / VTCN1 / B7-H4 Protein

Verwandte Produkte & Themen von B7S1 / VTCN1 / B7-H4 Protein

Immunology>>Cluster of Differentiation>>T Cell CD Antigen / B Cell CD Antigen / Dendritic Cell CD Antigen / Natural Killer (NK) Cell CD Antigen >>B7H4/B7X

Immunology>>Adaptive Immunity >>Costimulation & Costimulatory Molecule >>B7H4/B7X

Beschreibung von B7S1 / VTCN1 / B7-H4 Protein

V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass typeⅠ membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X / VTCN1 / B7H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, B7X / VTCN1 / B7H4 plays an important role, together with regulatory T-cells(Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. B7X / VTCN1 / B7H4 is also involved in promoting epithelial cell transformation. This membrane protein can be up-regulated by IL6 / interleukin-6 and IL10 / interleukin-10 and inhibited by CSF2 / GM-CSF and IL4 / interleukin-4 on antigen-presenting cells.

References

1. Zang X. et al., 2003, Proc Natl Acad Sci. 100 (18): 10388-92.
2. Suh WK. et al., 2006, Mol Cell Biol. 26 (17): 6403-11.
3. Zang X. et al., 2007, Proc Natl Acad Sci. 104 (49): 19458-63.