ASGR2 Protein (His Tag)

19.09.2012

Produkt-Information von ASGR2 Protein

Synonym	ASGR2, CLEC4H
Protein Construction	A DNA sequence encoding the human ASGR2 (P07307-1)(Gln80-Ala311) was expressed, with an N-terminal polyhistidine tag.
Source	Human
Expression Host	Human Cells

QC Testing von ASGR2 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: ASGR2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human ASGR2 comprises 252 amino acids and has a predicted molecular mass of 28.9 kDa. The apparent molecular mass of the protein is approximately 37-42 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von ASGR2 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von ASGR2 Protein

ASGR2 is a glycoprotein that forms the asialoglycoprotein receptor, also known as the Ashwell receptor, which is specific for desialylated (galactosyl-terminal) glycoproteins and is expressed exclusively in hepatic parenchymal cells. ASGR2 is a subunit of the asialoglycoprotein receptor. ASGR2 mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The asialoglycoprotein receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. ASGR2 is the less abundant minor subunit.

References

Davila S. et al., 2010, Genes Immun. 11 (3): 232-8.
Zhang X. et al., 2011, Arch Virol. 156 (4): 637-45.
Guy CS. et al., 2011, Hepatology. 54 (3): 1043-50.

Sino Biological Inc. liefert ASGR2 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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