ADM / Adrenomedullin Protein

06.06.2012

Produkt-Information von ADM / Adrenomedullin Protein

Synonym	ADM, AM
Protein Construction	A DNA sequence encoding the huamn ADM(P35318) (Tyr95-Tyr146) was expressed ,with the fused Fc region of human IgG1 at the N-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von ADM / Adrenomedullin Protein

Purity	> 93 % as determined by SDS-PAGE	SDS-PAGE: ADM / Adrenomedullin protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu
Molecular Mass	The recombinant human ADM/Fc is a disulfide-linked homodimer. The reduced monomer comprises 340 amino acids and has a predicted molecular mass of 38 kDa. The apparent molecular mass of the protein is approximately 39 in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS,pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von ADM / Adrenomedullin Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von ADM / Adrenomedullin Protein

Adrenomedullin is a a hypotensive peptide which consists of 52 amino acids and belongs to the adrenomedullin family. It has 1 intramolecular disulfide bond, and seems to has a slight homology with the calcitonin gene-related peptide. Adrenomedullin is highly expressed in pheochromocytoma and adrenal medulla. It also can be detected in lung, ventricle and kidney tissues. Adrenomedullin and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, adrenomedullin is diuretic and natriuretic, and both adrenomedullin and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. Adrenomedullin is believed to function through combinations of the calcitonin receptor like receptor and receptor activity-modifying proteins complexes, as well as CGRP receptors.

References

Hao SL. et al., 2011, Exp Lung Res. 37 (10): 615-26.
Hikosaka T. et al., 2011, Peptides. 32 (9): 1825-31.
Bo-Zalewska A. et al., 2011, Ginekol Pol. 82 (8): 585-91.
Palladini G. et al., 2011, Amyloid. 18 (4): 216-21.

Sino Biological Inc. liefert ADM / Adrenomedullin Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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