ACVR2A Antikörper (Antigen Affinität reinigt)

08.03.2012

Produkt-Information von ACVR2A Antikörper

Immunogen	Recombinant Human ACVR2A protein (Catalog#10257-H08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Human ACVR2A (rh ACVR2A;Catalog#10257-H08H; NP_001607.1; Met 1-Pro 134). ACVR2A specific IgG was purified by Human ACVR2A affinity chromatography.

ACVR2A Antikörper Usage Guide

Specificity	Human ACVR2A
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human ACVR2A in WB. Using a DAB detection system, the detection limit for Human ACVR2A is approximately 16 ng/lane under non-reducing conditions and 2 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human ACVR2A. The detection limit for Human ACVR2A is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von ACVR2A Antikörper

Verwandte Bereiche:

Proteine:

Antikörper:

Hintergrund von ACVR2A Antikörper

Activin isoforms which belong to the transforming growth factor-beta (TGF-β) superfamily exert their biological actions by binding to heteromeric receptor complexes consisting of at least a type I and a type II receptor of serine/threonine kinase These activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with serine/threonine kinase. Type I receptors are essential for signal transduction and type II receptors are required for ligand binding and the expression of type I receptors. On ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules including the endogenous Smads. Several type II activin receptors have been identified and bind to different activins with different affinities. Besides, this typeIIactivin receptor also bind inhibin, BMP-2 and BMP-7 with lower affinities.

References

Attisano, L. et al., 1996, Mol. Cell. Biol. 16: 1066-1073.
Hilden, K. et al., 1994, Blood, 83: 2163-2170.
Persson, U. et al., 1997, J. Biol. Chem. 272: 21187-21194.
Rosenzweig, B.L. 1995, Proc. Natl. Acad. Sci. 92: 7632-7636.

Sino Biological Inc. liefert ACVR2A Antikörper (Antigen Affinität reinigt) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über ACVR2A Antikörper (Antigen Affinität reinigt) lesen Sie bitte: http://www.sinobiological.com/ACVR2A-Antibody-g-8245.html