VEGF121 / VEGF-A Antikörper

Verwandte Bereiche:

Proteine:

Antikörper:

Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. As its name implies, VEGF-A activity has been mostly studied on cells of the vascular endothelium, although it does have effects on a number of other cell types (stimulation monocyte/macrophage, neurons, cancer cells, kidney epithelial cells). VEGF-A is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor. Alternatively spliced transcript variants of VEGF-A, encoding either secreted or cell-associated isoforms, have been identified. Alternatively spliced isoforms of 121,145,165,183,189 and 206 amino acids in length are expressed in humans. VEGF165 appears to be the most abundant and potent isoform and is a heparin-binding growth factor with mitogenic activity for vascular endothelial cells. Human VEGF165 shares 88%, 96%, 95% and 93% aa sequence identity with mouse, porcine, canine and feline VEGF165, respectively.

1. Mattei, M.G. et al., 1996, Genomics. 32 (1):168-169.
2. Borgatti, P. et al.,1998, Eur. J. Immunol. 27 (11): 2805-2811.
3. Gengrinovitch, S. et al., 1999, J Biol Chem. 274 (16):10816-10822.
4. Zachary, I. et al., 2001, Cardiovasc. Res. 49: 568-581.
5. Robinson, C.J. et al., 2001, J. Cell. Sci. 114: 853-865.
6. Lee, P. et al., 2002, Proc. Natl. Acad. Sci. USA. 99: 10470-10475.
7. Lee, G.Y. et al., 2006, Protein expressed and Purification. 46: 503-509.