UCHL1 Antikörper

09.08.2012

Produkt-Information von UCHL1 Antikörper

Immunogen	Recombinant Mouse UCHL1 protein (Catalog#50690-M07E)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse UCHL1 (rM UCHL1; Catalog#50690-M07E; Q9R0P9; Gln 2-Ala 223). Total IgG was purified by Protein A affinity chromatography.

Usage Guide von UCHL1 Antikörper

Specificity	Mouse UCHL1
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse UCHL1 in WB.
Direct ELISA	This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Mouse UCHL1. The detection limit for Mouse UCHL1 is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von UCHL1 Antikörper

Related Areas:

Neuroscience>>Neurodegenerative Disease>>Ubiquitin-proteasome pathway>>UCHL1

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
UCHL1	Human	UCHL1 Protein, Recombinant	11663-H07E
UCHL1	Mouse	UCHL1 Protein, Recombinant	50690-M07E
UCHL1	Rat	UCHL1 Protein, Recombinant	80089-R07E

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human UCHL1	WB, ELISA	UCHL1 Antibody, Rabbit MAb	11663-R104
Human UCHL1	WB, ELISA	UCHL1 Antibody, Rabbit PAb	11663-RP01
Human UCHL1	WB, ELISA	UCHL1 Antibody, Rabbit PAb (Antigen Affinity Purified)	11663-RP02
Mouse UCHL1	WB, ELISA	UCHL1 Antibody	50690-RP01
Mouse UCHL1	WB, ELISA	UCHL1 Antibody, Rabbit PAb (Antigen Affinity Purified)	50690-RP02
Rat UCHL1	WB, ELISA	UCHL1 Antibody (Antigen Affinity Purified)	80089-RP02

Hintergrund von UCHL1 Antikörper

Ubiquitin carboxyl-terminal hydrolase isozyme L1, also known as UCH-L1, Ubiquitin thioesterase L1, PGP9.5 and UCHL1, is a deubiqutinating enzyme with important functions in recycling of ubiquitin. Regulated proteolysis by the ubiquitin pathway has been implicated in control of the cell cycle, transcriptional activation, cell fate and growth, and synaptogenesis. The ubiquitin-proteasome system is involved in synaptic plasticity and is proposed to be part of a molecular switch that converts short-term synaptic potentiation to long-term changes in synaptic strength. UCHL1 is found in neuronal cell bodies and processes throughout the neocortex (at protein level). It is expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. UCHL1 is weakly expressed in ovary. UCHL1 is a ubiquitin-protein hydrolase. It is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer of UCHL1 may have ATP-independent ubiquitin ligase activity. UCHL1 dysfunction has been associated with neurodegeneration in Parkinson's, Alzheimer's, and Huntington's disease patients. Reduced UCHL1 function may jeopardize the survival of CNS neuron.

References

Wada H., et al., 1998, Biochem. Biophys. Res. Commun. 251:688-92.
Choi J., et al., 2004, J. Biol. Chem. 279: 13256-64.
Lombardino,A.2005, et al., J.Proc Natl Acad Sci.USA. 102 (22): 8036-41.
Okochi-Takada,E. et al., 2006, Int J Cancer. 119 (6): 1338-44.
Zetterberg, M. et al., 2010, Mol Neurodegener. 5:11.

Sino Biological Inc. liefert UCHL1 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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