Trypsin-3 / PRSS3 Antikörper

21.02.2012

Produkt-Information von Trypsin-3 / PRSS3 Antikörper

Immunogen	Recombinant Human Trypsin-3 / PRSS3 protein (Catalog#11866-H08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Human Trypsin-3 / PRSS3 (rh Trypsin-3 / PRSS3; Catalog#11866-H08H; P35030-3; Met 1-Ser 247). Total IgG was purified by Protein A affinity chromatography.

Trypsin-3 / PRSS3 AntikörperUsage Guide

Specificity	Human Trypsin-3 / PRSS3
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human PRSS3 in WB.
Direct ELISA	This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human PRSS3. The detection limit for Human PRSS3 is approximately 0.0195 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von Trypsin-3 / PRSS3 Antikörper

Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein which belongs to thepeptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains onepeptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their inhibitors seems to be important for the development of CP. The trypsin inhibitor-degrading activity qualified PRSS3 as a candidate for a novel CP susceptibility gene. Trypsin-3 / PRSS3 has been implicated as a putative tumor suppressor gene due to its loss of expression, which is correlated with promoter hypermethylation, in esophageal squamous cell carcinoma and gastric adenocarcinoma.

References

Venter JC. et al., 2001, Science 291: 1304-51.
Marsit,CJ. et al., 2005,Mol Carcinog44 (2): 146-50.
Rowen, L. et al., 2005, Mol Biol Evol. 22 (8): 1712-20.
Rosendahl, J. et al., 2010, Pancreatology. 10 (2-3): 243-9.

Sino Biological Inc. liefert Trypsin-3 / PRSS3 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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