TH / Tyrosine Hydroxylase Antikörper (Antigen Affinity Purified)

06.11.2012

Sino Biological Inc. liefert TH / Tyrosine Hydroxylase Antikörper (Antigen Affinity Purified) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über TH / Tyrosine Hydroxylase Antikörper (Antigen Affinity Purified) lesen Sie bitte: http://www.sinobiological.com/TH-Tyrosine-Hydroxylase-Antibody-g-10083.html

Produkt-Information von TH / Tyrosine Hydroxylase Antikörper

Immunogen	Recombinant Mouse TH / Tyrosine Hydroxylase protein (Catalog#50997-M07B)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse TH / Tyrosine Hydroxylase (rM TH / Tyrosine Hydroxylase; Catalog#50997-M07B; P24529; Pro 2-Ser 498). TH / Tyrosine Hydroxylase specific IgG was purified by Mouse TH / Tyrosine Hydroxylase affinity chromatography.

Usage Guide von TH / Tyrosine Hydroxylase Antikörper

Specificity

Mouse TH / Tyrosine Hydroxylase

Immunochemistry

IHC-P: 0.1-2 μg/mL

mTH-mouse-brain immunohistochemistry

Immunochemical staining of mouse TH in mouse brain with rabbit polyclonal antibody (1 μg/mL, formalin-fixed paraffin embedded sections).

Direct ELISA

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse TH.

Storage

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Hintergrund von TH / Tyrosine Hydroxylase Antikörper

Tyrosine Hydroxylase (TH, or TyrH) is the rate-limiting enzyme of catecholamine biosynthesis. Tyrosine Hydroxylase uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to DOPA. Its amino terminal 150 amino acids comprise a domain whose structure is involved in regulating the enzyme's activity. The TH enzyme is inhibited in feedback fashion by the catecholamine neurotransmitters. Dopamine binds to Tyrosine Hydroxylase competitively with tetrahydrobiopterin, and interacts with the R domain. Activity of tyrosine hydroxylase is regulated by feedback inhibition and inactivation by catecholamines, and activation by protein phosphorylation. Tyrosine Hydroxylase is modified in the presence of NO, resulting in nitration of tyrosine residues and the glutathionylation of cysteine residues. Tyrosine Hydroxylase involved in the pathogenesis of PD at several different levels, in addition to being a promising candidate for developing new treatments of this disease.

References

Fujisawa H. et al., 2005, Biochem Biophys Res Commun. 338 (1): 271-6.
Daubner SC. et al., 2011, 508 (1): 1-12.
Haavik J. et al., 1998, Mol Neurobiol. 16 (3): 285-309.

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Tyrosine Hydroxylase	Human	TH / Tyrosine Hydroxylase Protein, Recombinant	10684-H07B
Tyrosine Hydroxylase	Mouse	TH / Tyrosine Hydroxylase Protein, Recombinant	50997-M07B

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Mouse Tyrosine Hydroxylase	ELISA, IHC-P	TH / Tyrosine Hydroxylase Antibody (Antigen Affinity Purified)	50997-RP02

TH / Tyrosine Hydroxylase Antikörper (Antigen Affinity Purified)

Produkt-Information von TH / Tyrosine Hydroxylase Antikörper

Usage Guide von TH / Tyrosine Hydroxylase Antikörper

Verwandte Produkte & Themen von TH / Tyrosine Hydroxylase Antikörper

Hintergrund von TH / Tyrosine Hydroxylase Antikörper

References

Primary Antibody Products