TGFBR3 Antikörper

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Proteine:

Antikörper:

Transforming growth factor beta receptor type 3, also known as TGF-beta receptor type 3, TGFR-3, Transforming growth factor beta receptor III, Betaglycan, TGF-beta receptor type III and TGFBR3, is a single-pass type I membrane protein. TGFBR3 / Betaglycan is known to be expressed in adult testis and ovary. TGFBR3 / Betaglycan was expressed within the fetal testis interstitium, predominantly by Leydig cells, but expression shifted inside the seminiferous cords at birth. TGFBR3 / Betaglycan was detected in both the somatic and germ cell lineages in the fetal and neonatal ovary. This differential expression pattern suggests divergent roles for this TGFBR3 in developing testis and ovary. TGFBR3 / Betaglycan is the TGF-beta component most commonly downregulated among localized human prostate cancer. TGFBR3 / Betaglycan downregulation is an important step in prostate tumorigenesis. TGFBR3 / Betaglycan is an accessory receptor that binds to and modulates the activities of both transforming growth factor-beta (TGFbeta) and inhibin, two members of the TGFbeta superfamily of growth factors that regulate many aspects of reproductive biology.

1. Sharifi,N. et al., 2007, Prostate. 67 (3): 301-11.
2. Sarraj,M.A. et al., 2007, Growth Factors. 25 (5): 334-45.
3. Xiong,D.H. et al., 2009, Am J Hum Genet. 84 (3): 388-98.
4. Sarraj,M.A. et al., 2010,Biol Reprod. 82 (1): 153-62.