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Syndecan-1 / SDC1 / CD138 Antikörper (Antigen Affinity Purified)

Sino Biological Inc. liefert Syndecan-1 / SDC1 / CD138 Antikörper (Antigen Affinity Purified) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Syndecan-1 / SDC1 / CD138 Antikörper (Antigen Affinity Purified) lesen Sie bitte: http://www.sinobiological.com/Syndecan-1-SDC1-CD138-Antibody-g-10087.html

Produkt-Information von Syndecan-1 / SDC1 / CD138 Antikörper

Immunogen

Recombinant Human Syndecan-1 / SDC1 / CD138 protein (Catalog#11429-H08H)

Antibody Type Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type

Rabbit IgG

Formulation 0.2 μm filtered solution in PBS with 5% trehalose
Preparation

Produced in rabbits immunized with purified, recombinant Human Syndecan-1 / SDC1 / CD138 (rh Syndecan-1 / SDC1 / CD138; Catalog#11429-H08H; NP_002988.3; Met 1-Glu 251). Syndecan-1 / SDC1 / CD138 specific IgG was purified by Human Syndecan-1 / SDC1 / CD138 affinity chromatography.

Usage Guide von Syndecan-1 / SDC1 / CD138 Antikörper

Specificity

Human Syndecan-1 / SDC1 / CD138

Immunochemistry

IHC-P: 0.1-2 μg/mL

SDC1-breast-cancer immunohistochemistry    SDC1-colon-cancer immunohistochemistry

Immunochemical staining of human SDC1 in human breast cancer with rabbit polyclonal antibody (1 μg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to glandular epithelium. Immunochemical staining of human SDC1 in human colon cancer with rabbit polyclonal antibody (1 μg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to glandular epithelium.

SDC1-kidney immunohistochemistry    

Immunochemical staining of human SDC1 in human kidney with rabbit polyclonal antibody (1 μg/mL, formalin-fixed paraffin embedded sections).  
Storage This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von Syndecan-1 / SDC1 / CD138 Antikörper

Related Areas:

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Proteoglycan>>Syndecan-1/SDC1/CD138

Immunology>>Cluster of Differentiation>>Syndecan-1/SDC1/CD138

Proteins:
Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
Syndecan-1/SDC1/CD138 Human Syndecan-1/SDC1/CD138 Protein, Recombinant 11429-H08H
Syndecan-1/SDC1/CD138 Mouse Syndecan-1/SDC1/CD138 Protein, Recombinant 50641-M08H
Syndecan-1/SDC1 Rat SDC1 / Syndecan-1 / SYND1 Protein, Recombinant 80344-R02H
Syndecan-1/SDC1 Rat SDC1 / Syndecan-1 / SYND1 Protein, Recombinant 80344-R08H
Antibodies:
Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human Syndecan-1 / SDC1 / CD138 IHC-P Syndecan-1 / SDC1 / CD138 Antibody (Antigen Affinity Purified) 11429-RP02
Mouse Syndecan-1 / SDC1 / CD138 WB, ELISA Syndecan-1 / SDC1 / CD138 Antibody (Antigen Affinity Purified) 50641-RP02

Hintergrund von Syndecan-1 / SDC1 / CD138 Antikörper

Syndecan-1, also known as SYND1, CD138 and SDC1, is a single-pass type I membrane protein which belongs to thesyndecan proteoglycan family. CD138 / Syndecan-1, is well known to be associated with cell proliferation, adhesion, and migration in various types of malignancies. CD138 / Syndecan-1 is a cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. It is a cell-surface heparan sulfate proteoglycan expressed on most epithelial cells, and decreased CD138 expression is associated with increased invasive and metastatic potential in carcinomas. Within the hematopoietic system, CD138 is an excellent marker of plasmacytic differentiation. CD138 / Syndecan-1 is a cell surface proteoglycan that binds cells to the extracellular matrix and its expression is down-regulated in many cellular transformation models. CD138 / Syndecan-1 is a new simple non-invasive marker for predicting liver fibrosis in patients with chronic hepatitis C. The relevance of this marker in combination with other fibrosis markers should be explored. CD138 / Syndecan-1 might contribute to urothelial carcinoma cell survival and progression. It could be a new therapeutic target in human urinary bladder cancer.

References

  1. O'Connell, FP. et al., Am J Clin Pathol2004, 121 (2):254-63.
  2. Gokden,N.et al., 2006, Appl Immunohistochem Mol Morphol. 14 (2): 173-7.
  3. Sun,WP. et al., 2007, Cell Mol Immunol. 4 (3): 209-14.
  4. Zvibel, I. et al., 2009, Liver Int. 29 (2): 208-12.
  5. Shimada,K. et al., 2010, Cancer Sci. 101 (1): 155-60.

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