SIRT1 Antikörper

Verwandte Bereiche:

Proteine:

Antikörper:

NAD-dependent deacetylase sirtuin-1, also known as SIR2-like protein 1, SIRT1 and SIR2L1, is a nucleus protein which belongs to thesirtuin family. SIRT1 / SIR2L1 is widely expressed and contains onedeacetylase sirtuin-type domain. Mammalian SIRT1 is an NAD-dependent deacetylase with critical roles in the maintenance of homeostasis and cell survival. Elevated levels of SIRT1 protein are evident in cancer in which SIRT1 can function as a cancer-specific survival factor. SIRT1 / SIR2L1 regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. It deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce proapoptotic program and modulate cell senescence. SIRT1 / SIR2L1 deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I. It is involved in HES1- and HEY2-mediated transcriptional repression. It inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1. SIRT1 / SIR2L1 may serve as a sensor of the cytosolic ratio of NAD+/NADH, which is essential in skeletal muscle cell differentiation. In case of HIV-1 infection, it interacts with and deacetylates the viral Tat protein.

1. Vaziri H. et al., 2001, Cell 107: 149-59.
2. Langley E. et al., 2002, EMBO J. 21: 2383-96.
3. Bitterman K.J. et al., 2002, J. Biol. Chem. 277: 45099-107.
4. Takata T. et al., 2003, Biochem. Biophys. Res. Commun. 301: 250-7.
5. Pagans S. et al., 2005, PLoS Biol. 3: 210-20.
6. Ford,J. et al., 2008, Cell Cycle. 7 (19): 3091-7.