SFTPD / SP-D / SFTP4 Antikörper

27.02.2012

Produkt-Information von SFTPD / SP-D / SFTP4 Antikörper

Immunogen	Recombinant Cynomolgus SFTPD / SP-D / SFTP4 protein (Catalog#90003-C08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Cynomolgus SFTPD / SP-D / SFTP4 (rC SFTPD / SP-D / SFTP4; Catalog#90003-C08H; NP_001035283.1; Met 1-Phe 375). Total IgG was purified by Protein A affinity chromatography.

SFTPD / SP-D / SFTP4 Antikörper Usage Guide

Specificity	Cynomolgus SFTPD / SP-D / SFTP4
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Cynomolgus SFTPD in WB.
Direct ELISA	This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Cynomolgus SFTPD. The detection limit for Cynomolgus SFTPD is approximately 0.0049 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von SFTPD / SP-D / SFTP4 Antikörper

Surfactant, pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and contains one C-type lectin domain and one collagen-like domain. SP-D is assembled predominantly as dodecamers consisting of four set of homotrimers stabilized by interchain disulfide bonds involving two conserved amino-terminal cysteine residues. SP-D is produced primarily by alveolar type II cells and nonciliated bronchiolar cells in the lung and is constitutively secreted into the alveoli where it influences surfactant homeostasis, effector cell functions, and host defense. It is upregulated in a variety of inflammatory and infectious conditions including Pneumocystis pneumonia, asthma, and bleomycin injury. Mice or rats exposed to hyperoxic challenge also have increases in SP-D, suggesting that it may have a role in protection from this insult.

References

Liu, Y. et al., 1994, J. Immunol. 152:1821-1829.
Kotenko, S.V. et al.,1997, EMBO J. 16 (19): 5894-5903.
Gibbs, V. C. et al., 1997, Pennica. Gene 186: 97-101.
Kotenko, S.V. et al., 2001, J. Biol. Chem. 276: 2725-2732.
Crepaldi, L. et al., 2001, J. Immunol. 167: 2312-2322.
Dinant, S. J. et al., 2007, Surg Res. 141 (2): 176-82.

Sino Biological Inc. liefert SFTPD / SP-D / SFTP4 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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