SerpinB6 Antikörper

13.02.2012

Produkt-Information von SerpinB6 Antibody Product Information

Immunogen	Recombinant Human SerpinB6 protein (Catalog#12837-H07B)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Human SerpinB6 (rh SerpinB6;Catalog#12837-H07B; AAB30320.1; Asp 2-Pro 376). Total IgG was purified by Protein A affinity chromatography.

SerpinB6 AntikörperUsage Guide

Specificity	Human SerpinB6
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human Serpinb6 in WB.
Direct ELISA	This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human Serpinb6. The detection limit for Human Serpinb6 is approximately 0.00245 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von SerpinB6 Antikörper

SerpinB6, also known as Cytoplasmic antiproteinase, Peptidase inhibitor 6, Placental thrombin inhibitor, SERPINB6 and PI-6, is a cytoplasm protein which belongs to the serpin family and Ov-serpin subfamily. SerpinB6 / PI-6 is an inhibitor of cathepsin G, kallikrein-8 and thrombin. It may play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. SerpinB6 / PI-6 is expressed in keratinocytes (at protein level). It is also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. SerpinB6 / PI-6 is expressed in the inner ear hair cells. It expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions. SerpinB6 / PI-6 may be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Defects in SerpinB6 are the cause of deafness autosomal recessive type 91 which is a form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal.

References

Morgenstern KA. et al.,1994, Biochemistry. 33: 3432-41.
Strik MC. et al., 2004, Blood. 103: 2710-7.
Scott FL. et al., 2007, J Biochem. 142: 435-42.
Burkard TR. et al., 2011, BMC Syst Biol. 5:17.

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