Semaphorin 6A / SEMA6A Antikörper

15.02.2012

Produkt-Information von Semaphorin 6A / SEMA6A Antibkörper

Immunogen	Recombinant Human Semaphorin 6A / SEMA6A protein (Catalog#11189-H08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Human Semaphorin 6A / SEMA6A (rh Semaphorin 6A / SEMA6A; Catalog#11189-H08H; NP_065847.1; Met 1-Thr 649). Total IgG was purified by Protein A affinity chromatography.

Semaphorin 6A / SEMA6A Antikörper Usage Guide

Specificity	Human Semaphorin 6A / SEMA6A
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human SEMA6A in WB.
Direct ELISA	This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human SEMA6A. The detection limit for Human SEMA6A is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von Semaphorin 6A / SEMA6A Antikörper

Semaphorin-6A, also known as Semaphorin VIA and SEMA6A, is a single-pass type I membrane protein which belongs to thesemaphorin family. Semaphorin-6A / SEMA6A contains onePSI domain and oneSema domain. Semaphorin-6A / SEMA6A can act as repulsive axon guidance cues. It may play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-rich semaphorin protein domains, that have important roles in a variety of tissues. Humans have 20 semaphorins, Drosophila has five, and two are known from DNA viruses. Semaphorins are found in nematodes and crustaceans but not in non-animals. They are grouped into eight classes on the basis of phylogenetic tree analyses and the presence of additional protein motifs. Semaphorins have been implicated in diverse developmental processes such as axon guidance during nervous system development and regulation of cell migration.

References

Klostermann A. et al., 2000, J Biol Chem. 275: 39647-53.
Nagase T. et al., 2000, DNA Res. 7: 65-73.
Schmutz J. et al., 2004, Nature. 431: 268-74.
Neufeld G. et al., 2005, Front Biosci. 10: 751-60.
Fiore R. et al., 2005, Mol Cell Biol. 25 (6): 2310-9.

Sino Biological Inc. liefert Semaphorin 6A / SEMA6A Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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