S100A3 Antikörper (Antigen Affinität reinigt)

13.02.2012

Produkt-Information von S100A3 Antikörper

Immunogen	Recombinant Human S100A3 protein (Catalog#11136-H10E)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose

S100A3 Antikörper Usage Guide

Specificity	Human S100A3
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human S100A3 in WB. Using a DAB detection system, the detection limit for Human S100A3 is approximately 1 ng/lane under non-reducing conditions and 0.5 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human S100A3. The detection limit for Human S100A3 is approximately 0.00245 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produte & Themen von S100A3 Antikörper

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Hintergrund von S100A3 Antikörper

Protein S100-A3, also known as Protein S-100E, S100 calcium-binding protein A3, S100A3 and S100E, is a member of the S-100 family. S100A3 / S100E contains 2EF-hand domains. S100A3 / S100E is highly expressed in the differentiating cuticular cells within the hair follicle and organized into mature hair cuticles. High concentrations of S100A3 homotetramer might provide the millimolar level of Ca2+ required for hair cuticular barrier formation. S100A3 / S100E is a unique member of the Ca2+-binding S100 protein family with the highest cysteine content and affinity for Zn2+. S100A3 / S100E binds both calcium and zinc. S100A3 / S100E probably binds 2 zinc ions per molecule. It may be involved in calcium-dependent cuticle cell differentiation and hair shaft formation. S100A3 plays an important role in calcium-dependent processes leading to hair shaft formation. S100A3 / S100E is a unique protein among all members of the calcium-binding S100 family, is specifically expressed at the inner endocuticle of human hair fibers. Upon hair damage, S100A3 / S100E is released from hair fibers and possibly destabilizes the hair tissue architecture.

References

Kizawa, K. et al., 2008,J Biol Chem. 283 (8): 5004-13.
Kizawa, K. et al., 1998,J Invest Dermatol. 111 (5): 879-86.
Kizawa, K. et al., 2002, Biochem Biophys Res Commun. 299 (5): 857-62.
Fritz,G. et al., 2002, J Biol Chem. 277 (36): 33092-8.

Sino Biological Inc. liefert S100A3 Antikörper (Antigen Affinität reinigt) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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