Rat IL7R / IL7RA Protein

Sino Biological Inc. liefert Rat IL7R / IL7RA Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Produkt-Information von IL7R / IL7RA Protein

QC Testing von IL7R / IL7RA Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: IL7R / IL7RA protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu 21
Molecular Mass	The recombinant rat IL7R /Fc comprises 453 amino acids and has a predicted molecular mass of 51.4 kDa. The apparent molecular mass of the protein is approximately 65 in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL7R / IL7RA Protein

Verwandte Produkte & Themen von IL7R / IL7RA Protein

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>CD127/IL-7RA

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>CD127/IL-7RA

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD127/IL-7RA

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Monocyte Markers>>CD127/IL-7RA

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells / Regulatory T Cells>>CD127/IL-7RA

Beschreibung von IL7R / IL7RA Protein

Interleukin 7 Receptor alpha ( IL-7Rα ), also known as CD127, is a hematopoietin receptor superfamily member that plays an important role in lymphocyte differentiation, proliferation, and survival. IL-7Rα is majorly expressed on T cells and their precursors, and early in B cell development as well, prior to the appearance of surface IgM. Mature human IL-7Rα consists of a 219 aa extracellular domain (ECD) with one fibronectin type-III domain and a WSxWS motif, a 25 aa transmembrane segment, and a 195 aa cytoplasmic domain. Within the ECD, human IL-7Rα shares 67% aa sequence identity with mouse IL-7Rα. Mutations in the human IL-7Rα gene cause a type of severe combined immunodeficiency in which the major deficiencies are in T cell development, whereas B and NK cells are relatively normal in number. Therefore, the IL-7Rα is critically required for the proper development and function of lymphoid cells. In addition to IL-7, IL-7Rα also associates with TSLPR to form the functional receptor for thymic stromal lymphopoietin (TSLP) which indirectly regulates T cell development by modulating dendritic cell activation. Dynamic regulation of IL-7Rα is important for the generation of appropriate immune responses.

References

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6. Mazzucchelli R. et al., 2007, Nat Rev Immunol. 7:144-54.
7. Vranjkovic A. et al., 2007, Int Immunol. 19: 1329-39.