Rat GP1BB Protein

03.01.2013

Sino Biological Inc. liefert Rat GP1BB Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat GP1BB Protein lesen Sie bitte: http://www.sinobiological.com/GP1BB-Protein-g-10263.html

Produkt-Information von GP1BB Protein

Synonym	GP1BB
Protein Construction	A DNA sequence encoding the rat GP1BB (Q9JJM7) (Met1-Cys147) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Rat
Expression Host	Human Cells

QC Testing von GP1BB Protein

Purity	> 85% as determined by SDS-PAGE	SDS-PAGE: GP1BB protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Pro 27
Molecular Mass	The recombinant rat GP1BB/Fc is a disulfide-linked homodimer. The reduced monomer comprises 359 amino acids and has a predicted molecular mass of 40.1 kDa. The apparent molecular mass of the protein is approximately 63 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von GP1BB Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von GP1BB Protein

GP1BB, also known as CD42C, is the beta chain of platelet glycoprotein Ib (GPIb). GPIb is a heterodimeric transmembrane protein. GPIb is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor, and mediates platelet adhesion in the arterial circulation. It consists of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. GPIb alpha chain provides the VWF binding site, and GP1BB contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain.

References

Andrews RK. et al., 1990, Biochemistry. 28 (21): 8317-26.
Clemetson KJ. 2007, Thromb Haemost. 98 (1): 63-8.
Kunishima S. et al., 2003, Int J Hematol. 76 (4): 319-27.