Rat GITR / TNFRSF18 Protein

03.01.2013

Sino Biological Inc. liefert Rat GITR / TNFRSF18 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat GITR / TNFRSF18 Protein lesen Sie bitte: http://www.sinobiological.com/GITR-TNFRSF18-Protein-g-10261.html

Produkt-Information von GITR / TNFRSF18 Protein

Synonym	TNFRSF18
Protein Construction	A DNA sequence encoding the rat TNFRSF18 (Q5M835) (Met1-Lys121) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Rat
Expression Host	Human Cells

QC Testing von GITR / TNFRSF18 Protein

Purity	> 95% as determined by SDS-PAGE	SDS-PAGE: GITR protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu 25
Molecular Mass	The recombinant rat TNFRSF18/Fc is a disulfide-linked homodimer. The reduced monomer comprises 338 amino acids and has a predicted molecular mass of 37.7 kDa. The apparent molecular mass of the protein is approximately 47 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von GITR / TNFRSF18 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von GITR / TNFRSF18 Protein

GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death.

References

Won B. et al., 1999, J Biol Chem. 274 (10): 6056-61.
Nocentini G. et al., 1997, Proc Natl Acad Sci. 94 (12): 6216-21.
Kim YS. et al., 2007, Oncol Rep. 18 (5): 1189-94.