Rat FGFR4 / FGF Receptor 4 Protein (His Tag)

Produkt-Information von FGFR4 / FGF Receptor 4 Protein

QC Testing von FGFR4 / FGF Receptor 4 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: FGFR4 / FGF Receptor 4 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Phe 17
Molecular Mass	The recombinant rat FGFR4 comprises 362 amino acids and predicts a molecular mass of 40.3 kDa. The apparent molecular mass of the rat FGFR4 is approximately 64-68 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von FGFR4 / FGF Receptor 4 Protein

Verwandte Produkte & Themen von FGFR4 / FGF Receptor 4 Protein

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>FGFR4/CD334

Neuroscience>>Axon Guidance>>FGF & Receptor>>FGFR4/CD334

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>FGFR4/CD334

Stem Cell>>Neural Stem Cell (NSC)>>Neural Stem Cell Markers>>FGFR4/CD334

Stem Cell>>Neural Stem Cell (NSC)>>Glial Cell Markers>>FGFR4/CD334

Cancer>>Growth Factor & Receptor>>FGF & Receptor>>FGFR4/CD334

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>FGFR4/CD334

Immunology>>Cluster of Differentiation>>Other>>FGFR4/CD334

Beschreibung von FGFR4 / FGF Receptor 4 Protein

FGFR4, also designated as CD334, is a member of the fibroblast growth factor receptor subfamily which belongs to the tyrosine protein kinase superfamily. Upon ligand binding, FGFRs undergo dimerization and autophosphorylation, intiating a cascade of downstream signal pathways, ultimately influencing a variety of physiological and pathological cellular processes including mitogenesis and differentiation. FGFR members is highly conserved in amino acid sequence and differ in their ligand affinities and tissue distribution. FGFR4, a type I transmembrane glycoprotein, contains 3 immunoglobulin-like domains in the extracellular domain and a cytoplasmic tyrosine-kinase domain. FGFR4 expression is detected in gastrointestinal epithelial cells, pancreas, as well as gastric and pancreatic cancer cell lines. FGFR4 is reported to be a high affinity receptor for both acidic and basic fibroblast growth factor, and also binds to FGF19. Like FGFR1-3, several isoforms of FGFR4 are generated by alternative splicing of the mRNAs. Although its specific function is unknown, growing studies have indicated that FGFR4 plays a role in tumorigenesis and malignace of cetain carcinomas such as breast and ovarian tumors.

References

1. Partanen J. et al., 1991, EMBO J. 10: 1347-54.
2. Ron D. et al., 1993, J Biol Chem. 268: 5388-94.
3. Marics I. et al., 2002, Development. 129: 4559-69.
4. Bnage J. et al., 2002, Cancer Res. 62: 840-7.

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