Rat ESAM Protein

10.04.2012

Produkt-Information von ESAM Protein

Synonym	ESAM
Protein Construction	A DNA sequence encoding the rat ESAM (Q6AYD4) extracellular domain (Met 1-Ala 251) was fused with the Fc region of human IgG1 at the C-terminus.
Source	Rat
Expression Host	Human Cells

QC Testing von ESAM Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: ESAM protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gln 30
Molecular Mass	The recombinant rat ESAM/Fc is a disulfide-linked homodimer. The reduced monomer comprises 463 amino acids and predicts a molecular mass of 51.2 kDa. The apparent molecular mass of the rat ESAM/Fc monomer is approximately 55-60 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von ESAM Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Verwandte Produkte & Themen von ESAM Protein

Related Areas:

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>ESAM

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>ESAM

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>ESAM

Immunology>>Adhesion Molecule>> Cell Adhesion Molecule (IgSF CAM)>>ESAM

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
ESAM	Human	ESAM/Fc Protein, Recombinant	10187-H02H
ESAM	Human	ESAM/Fc Protein, Recombinant	10187-H08H
ESAM	Human	ESAM Protein, Recombinant	10187-HCCH
ESAM	Mouse	ESAM Protein, Recombinant	50977-M08H
ESAM	Rat	ESAM Protein, Recombinant	80241-R02H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat No
Human ESAM	WB, ELISA	ESAM Antibody, Mouse MAb	10187-MM01
Human ESAM	WB, ELISA	Rabbit Polyclonal Antibody	10187-RP01
Human ESAM	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10187-RP02

Beschreibung von ESAM Protein

Endothelial cell-selective adhesion molecule (ESAM) is a member of JAM family of immunoglobulin superfamily and consists of one V-type and one C2-type immunoglobulin domain, as well as a hydrophobic signal sequence, a single transmembrane region, and a cytoplasmic domain. ESAM is specifically expressed at endothelial tight junctions and on activated platelets and performs homophilic adhesion activity. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. In addition, ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. ESAM-deficient mice were described with lowered angiogenic potential, and accordingly, overexpression of ESAM is closely associated with certain tumor growth and metastasis.

References

Hirata Ki. et al., 2001, J Biol Chem. 276: 16223-31.
Ishida T. et al., 2003, J Biol Chem. 278: 34598-604.
Wegmann F. et al., 2006, J Exp Med. 203: 1671-7.
Wegmann F. et al., 2004, Exp Cell Res. 300: 121-33.
Clasper S. et al., 2008, Cancer Res. 68: 7293-303.

Sino Biological Inc. liefert Rat ESAM Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat ESAM Protein lesen Sie bitte: http://www.sinobiological.com/ESAM-Protein-g-8673.html