Rat EFNA1 / EphrinA1 Protein (His Tag)

Produkt-Information von EFNA1 / EphrinA1 Protein

QC Testing von EFNA1 / EphrinA1 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: EFNA1 / EphrinA1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ala 18
Molecular Mass	The recombinant rat EFNA1 comprises 175 amino acids and predicts a molecular mass of 20.7 kDa. The apparent molecular mass of the rat EFNA1 is approximately 27 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von EFNA1 / EphrinA1 Protein

Verwandte Produkte & Themen von EFNA1 / EphrinA1 Protein

Neuroscience>>Axon Guidance>>Ephrin & Eph Receptor>>Ephrin-A1/EFNA1

Cancer>>Growth Factor & Receptor>>Ephrin & Eph Receptor>>Ephrin-A1/EFNA1

Beschreibung von EFNA1 / EphrinA1 Protein

The ephrins (Eph) and Eph receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. All ephrins share a conserved extracellular sequence, which most likely corresponds to the receptor-binding domain. In?molecular biology , ephrins and Eph receptors are components of cell signaling pathways involved in animal development, and implicated in some cancers. Eph receptors are classified as receptor tyrosine kinases (RTKs), and form the largest sub-family of RTKs. Almost all Eph receptors are expressed during various well defined stages of development in assorted locations and concentrations. Ephrin-A1, also known as B61, LERK-1, and EFL-1, is a member of the ephrin ligand family which binds members of the Eph receptor family. Ephrin-A1 has been shown to bind EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, and EphB1. The extracellular domains of human and mouse ephrin-A1 share 85% amino acid identity.

References

1. Cerretti DP. et al., 1995, Mol Immunol. 32 (16): 1197-205.
2. Gale NW. et al.,1996, Neuron.17 (1): 9-19.
3. Pasquale EB. et al., 1997, Curr Opin Cell Biol. 9 (5): 608-15.
4. Flanagan J. et al., 1998, Annual Review of Neuroscience. 21: 309-45.
5. Holder N. et al., 1999, Development. 126 (10): 2033-44.
6. Wilkinson DG. et al., 2001, Nat Rev Neurosci. 2 (3): 155-64.
7. Murai KK. et al., 2003, Journal of Cell Science. 116 (14): 2823-32.

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