Rat CD70 Protein

Sino Biological Inc. liefert Rat CD70 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat CD70 Protein lesen Sie bitte: http://www.sinobiological.com/CD70-Protein-g-10000.html

Produkt-Information von CD70 Protein

QC Testing von CD70 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: CD70 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu
Molecular Mass	The recombinant rat CD70 comprises 410 amino acids and predicts a molecular mass of 45 kDa. The apparent molecular mass of  the recombinant protein is approximately 55 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD70 Protein

Verwandte Produkte & Themen von CD70 Protein

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CD70/CD27L/TNFSF7

Immunology>>Cytokine & Receptor>>TNF Superfamily>>CD70/CD27L/TNFSF7

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD70/CD27L/TNFSF7

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>CD70/CD27L/TNFSF7

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>CD70/CD27L/TNFSF7

Beschreibung von CD70 Protein

CD70, also known as CD27 ligand (CD70 / CD27L / TNFSF7), is a member of the tumor necrosis factor superfamily (ie. TNFSF7) and a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. CD70 is a single-pass type Ⅲ transmebrane glycoprotin consisting of a short cytoplasmic domain (1-17aa) , a transmembrane domain (18-38 aa) and a 155aa extracellular domain (39-193), and exists as a homotrimer in vivo. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 expression on malignant cells coupled with its highly restricted expression on normal cells makes CD70 an attractive target for monoclonal antibody -based therapies.

References

1. Goodwin RG. et al., 1993, Cell. 73: 447-56.
2. Boursalian TE. et al., 2009, Adv Exp Med Biol. 647: 108-19.
3. Bowman MR. et al., 1994, J Immunol. 152: 1756-61.
4. McEarchern JA. et al., 2008, Clin Cancer Res. 14 (23): 7763-72.
5. Tesselaar K. et al., 2002, J Immunol. 169: 33-40.