Rat CADM3 / IGSF4B / NECL1 Protein (His Tag)

Produkt-Information von CADM3 / IGSF4B / NECL1 Protein

QC Testing von CADM3 / IGSF4B / NECL1 Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: CADM3 / IGSF4B / NECL1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Asn 23
Molecular Mass	The recombinant rat CADM3 comprises 317 amino acids and predicts a molecular mass of 35 kDa. The apparent molecular mass of the ratCADM3 is approximately 35-40 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.5 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

CADM3 / IGSF4B / NECL1 Protein Usage Guide

Verwandte Produkte & Themen von CADM3 / IGSF4B / NECL1 Protein

Neuroscience>>Synaptic Protein>>CADM3/NECL1/IGSF4B

Immunology>>Adhesion Molecule>> Cell Adhesion Molecule (IgSF CAM) >>CADM3/NECL1/IGSF4B

Beschreibung von CADM3 / IGSF4B / NECL1 Protein

Cell Adhesion Molecules (CAMs) are proteins located on the cell surface involved with the binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion. These proteins are typically transmembrane receptors and are composed of three domains: an intracellular domain that interacts with the cytoskeleton, a transmembrane domain, and an extracellular domain that interacts either with other CAMs of the same kind (homophilic binding) or with other CAMs or the extracellular matrix (heterophilic binding). Cell adhesion molecule 3, also known as Immunoglobulin superfamily member 4B, CADM3, and NECL1, is a member of the nectin family. It contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 of CADM3 is expressed mainly in adult and fetal brain. Isoform 2 of CADM3 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. CADM3 is involved in the cell-cell adhesion. It has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. The interaction with EPB41L1 may regulate structure or function of cell-cell junctions.

References

1. Fukuhara H. et al., 2001, Oncogene. 20: 5401-7.
2. Clark HF. et al., 2003, Genome Res. 13: 2265-70.
3. Zhou Y. et al., 2005, Biochim Biophys Acta. 1669: 142-54.
4. Dong X. et al., 2006 J Biol Chem. 281: 10610-7.

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