NELL2 / NRP2 Protein (His Tag)

Protein kinase C-binding protein NELL2 is a neuron-specific thrombospondin-1 like extracellular protein that contains epidermal growth factor (EGF) – like repeats and several von Willebrand factor C domains. NELL2 acts as a homotrimer and plays a key role in neural cell growth and differentiation as well as in oncogenesis. NELL2 is highly expressed in the hippocampus and cerebral cortex. This extracellular protein increased survival of neurons from the hippocampus and cerebral cortex and did not protect neurons from oxygen-glucose deprivation- and beta-amyloid-induced neuronal death. NELL2-enhanced survival of hippocampal neurons was completely blocked by SP600125, an anthrapyrazolone inhibitor of JNK, while treatment of MEK (MAPK / ERK kinase) inhibitors per se enhanced survival of neurons similar to NELL2 treatment. All of these suggest that NELL2 promotes survival of neurons by modulating MAPk activities. It has been proved that NELL2 is highly regulated spatially and temporally, being only transiently expressed in discrete regions of the central (CNS) an peripheral nervous systems (PNS) and in a subset of mesoderm derived structures during their peak periods of development.

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