MSR1 / CD204 Antikörper (Antigen Affinität reinigt)

06.03.2012

Produkt-Information von MSR1 / CD204 Antikörper

Immunogen	Recombinant Mouse MSR1 / CD204 protein (Catalog#50129-M07H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse MSR1 / CD204 (rM MSR1 / CD204; Catalog#50129-M07H; AAH03814.1; Trp 83-Val 354). MSR1 / CD204 specific IgG was purified by Mouse MSR1 / CD204 affinity chromatography.

MSR1 / CD204 Antikörper Usage Guide

Specificity	Mouse MSR1 / CD204
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse MSR1 in WB. Using a DAB detection system, the detection limit for Mouse MSR1 is approximately 2 ng/lane under non-reducing conditions and 1 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse MSR1. The detection limit for Mouse MSR1 is approximately 0.00245 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von MSR1 / CD204 Antikörper

Macrophage scavenger receptor types I and II, also known as Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD204, MSR1 and SCARA1, is a single-pass type II membrane protein which contains onecollagen-like domain and oneSRCR domain. Macrophages are distributed in all peripheral tissues and play a critical role in the first line of the innate immune defenses against bacterial infection by phagocytosis of bacterial pathogens through the macrophage scavenger receptor 1 (MSR1). MSR1 / SCARA1 is one of the membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). MSR1 / SCARA1 is also involved in chronic inflammation which is a risk factor for prostate cancer. MSR1 1 gene was identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer.

References

Wang,L.et al., 2003, Nat Genet. 35 (2): 128-9.
Chen,Y.C. et al., 2008, Cancer Epidemiol Biomarkers Prev17 (4): 1001-3.
Shirato,K. et al., 2009,Pflugers Arch459 (1): 93-103.
Sun,J.et al., 2006, Prostate. 66 (7): 728-37.

Sino Biological Inc. liefert MSR1 / CD204 Antikörper (Antigen Affinität reinigt) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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