Mouse TNFSF11 / OPGL / CD254 Protein

30.03.2012

Produkt-Information von TNFSF11 / OPGL / CD254 Protein

Synonym	Ly109l, ODF, OPG, OPGL, RANKL, Trance
Protein Construction	A DNA sequence encoding the extracellular domain of mouse TNFSF11 (BAA97257.1) (Arg 72-Asp 316) was fused with the Fc region of human IgG1 at the N-terminus.
Source	Mouse
Expression Host	Human Cells

QC Testing von TNFSF11 / OPGL / CD254 Protein

Purity	> 87 % as determined by SDS-PAGE	SDS-PAGE: TNFSF11 / OPGL / CD254 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu
Molecular Mass	The recombinant mouse TNFSF11/Fc is a disulfide-linked homodimer. The reduced monomer comprises 505 amino acids and has a calculated molecular mass of 56 kDa. The apparent molecular mass of the monomer is approximately 50 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

TNFSF11 / OPGL / CD254 Protein Usage Guide

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von TNFSF11 / OPGL / CD254 Protein

TNFSF11(tumor necrosis factor (ligand) superfamily, member 11,human IgG1-Fc chimera), also known as OPGL and CD254, is a member of the tumor necrosis factor (TNF) cytokine family. TNFRSF11A and OPG, cooperating with prostaglandin, mediating osteoclastognesis and bone loss through systemic activation of T cells, regulating lymph node organogenesis lymphocyte development and interactions between T cells and dendritic cells, activating the antiapoptotic serine threonine kinase AKT/PKB through a signal complex involving TRAF6 and SRC. TNFSF11 is a cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. It augments the ability of dendritic cells to stimulate naive T-cell proliferation. TNFSF11 may be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. It may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Defects in TNFSF11 are the cause of osteopetrosis autosomal recessive type 2.

References

Wong BR. et al., 1997, J Biol Chem. 272 (40): 25190-4.
Anderson DM. et al., 1997, Nature. 390 (6656): 175-9.
Schramek D. et al., 2010, Nature. 468(7320): 98-102.
Gonzalez-Suarez E. et al., 2010, Nature. 468 (7320): 103-7.

Sino Biological Inc. liefert Mouse TNFSF11 / OPGL / CD254 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
RANKL / OPGL / TNFSF11	Human	RANKL / OPGL / TNFSF11 Protein, Recombinant	11682-H01H
RANKL / OPGL / TNFSF11	Mouse	RANKL / OPGL / TNFSF11 Protein, Recombinant	50343-M01H