Mouse Tie2 / TEK Protein (His Tag)

Produkt-Information von Tie2 / TEK Protein

QC Testing von Tie2 / TEK Protein

Purity	>99% as determined by SDS-PAGE	SDS-PAGE: Tie2 / TEK protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Val 19
Molecular Mass	The recombinant mouse TEK comprises 737 amino acids and has a predicted molecular mass of 82.4 kDa. The apparent molecular mass of the protein is approximately 91 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von Tie2 / TEK Protein

Verwandte Produkte & Themen von Tie2 / TEK Protein

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>Tie2/CD202b

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>Tie2/CD202b

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Hemangioblast Marker>>Tie2/CD202b

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>Tie2/CD202b

Cancer>>Growth Factor & Receptor>>Angiopoietin/Tie>>Tie2/CD202b

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>Tie2/CD202b

Immunology>>Cluster of Differentiation>>Other>>Tie2/CD202b

Beschreibung von Tie2 / TEK Protein

Tie2/Tek, together with Tie1/Tie, are members of the receptor tyrosine kinase (RTK) subfamily, and possess a unique extracellular domain containing two immunoglobulin-like loop domains flanking three epidermal growth factor (EGF) repeats followed by three fibronectin-type I II repeats, and a split tyrosine kinase domain in the cytoplasmic region. Tie2 is expressed predominantly on endothelial and hematopoietic progenitor cells and is essential for blood vessel formation and maintenance. The identified ligand angiopoietin-1 (Ang-1) binds Tie2 receptor with high-affinity and induces the signaling pathway of both cell migration and cell survival via the related mediator such as GRB2 and SH-PTP2. Accordingly, the Tie2 may trigger crucial endothelial responses during embryonic vascular development and during pathologic vascular growth, as well as the inflammatory responses with the key regulator ABIN-2. Recent study has revealed that Ang1-Tie2 signaling exerts different function at cell-cell contacts and cell-substratum contacts dependent upon the spatial localization of Tie2. Deficiency in this gene is associated with inherited venous malformations.

References

1. Partanen J. et al., 1992, Mol Cell Biol. 12: 1698-707.
2. Sato TN. et al., 1993, Proc. Natl. Acad. Sci. 90: 9355-8.
3. Jones N. et al., 1999, J. Biol. Chem. 274: 30896-905.
4. Fukuhara S. et al., 2008, Nat. Cell. Biol. 10: 513-26.
5. Marron MB. et al., 2007, J Biol Chem. 282: 30509-17.
6. Huqhes DP. et al., 2003, Circ Res. 92: 630-6.

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