Mouse Prostasin / PRSS8 (aa 30-289) Protein (His Tag)

Produkt-Information von Prostasin / PRSS8 Protein

QC Testing von Prostasin / PRSS8 Protein

Purity	> 97 % as determined by SDS-PAGE	SDS-PAGE: Prostasin / PRSS8 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ala 30
Molecular Mass	The secreted recombinant mouse PRSS8 consists of 270 amino acids and has a calculated molecular mass of 29.3 kDa. It migrates as an approximately 35 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of 20mM Tris, 500mM NaCl, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von Prostasin / PRSS8 Protein

Verwandte Produkte & Themen von Prostasin / PRSS8 Protein

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Prostasin/PRSS8

Beschreibung von Prostasin / PRSS8 Protein

Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays important roles in epithelial physiology. It is originally purified as an active, soluble enzyme from human seminal fluid and is highly expressed in prostate, lung, kidney, salivary gland and pancreas. Prostasin is expressed as a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein in prostate epithelial cells, and also exists as a secreted proteolytic enzyme possibly via tryptic cleavage of its COOH-terminal hydrophobic domain. Prostasin is found to activate the epithelial sodium channel (ENaC) which is tightly regulated and is critical for maintaining salt and fluid balance in the lung and kidney in both normal and pathological conditions. Accordingly, prostasin has been proposed as a target for therapeutic inhibition in cystic fibrosis. In addition, prostasin inhibits prostate and breast cancer cell invasion in vitro, suggesting a functional role as a suppressor of tumor invasion, as well as a regulator of gene expression during inflammation.

References

1. Yu JX. et al., 1994, J Biol Chem. 269: 18843-8.
2. Chen LM. 2001, J Biol Chem. 276: 21434-42.
3. Chen LM. et al., 2002, Int J Cancer. 97: 323-9.
4. Chen M. et al., 2007, Biochim Biophys Acta. 1733: 1133-40.
5. Verghese GM. et al., 2006, Am J Physiol Cell Physiol. 291: c1285-1270.

Sino Biological Inc. liefert Mouse Prostasin / PRSS8 (aa 30-289) Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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