Mouse MFI2 / CD228 / melanotransferrin Protein

Produkt-Information von MFI2 / CD228 / melanotransferrin Protein

QC Testing von MFI2 / CD228 / melanotransferrin Protein

Purity	> 92 % as determined by SDS-PAGE	SDS-PAGE: MFI2 / CD228 / melanotransferrin protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Val 20
Molecular Mass	The secreted recombinant mouse MFI2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 930 amino acids and has a calculated molecular mass of 103 kDa. The apparent molecular mass of rmMFI2/Fc monomer is approximately 100 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

MFI2 / CD228 / melanotransferrin Protein Usage Guide

Verwandte Produkte & Themen von MFI2 / CD228 / melanotransferrin Protein

Immunology>>Cluster of Differentiation>> MTf / Melanotransferrin

Beschreibung von MFI2 / CD228 / melanotransferrin Protein

The melanotransferrin (MTf) molecule, also called CD228 or p97, has been widely described as a melanoma specific molecule. MTf is found at high levels in melanoma cells and previous studies have shown that MTf can bind Fe. MTf has a high level of sequence homology to transferrin (Tf) and lactoferrin, but is unusual because it predominantly occurs as a membrane bound, glycosylphosphatidylinositol (GPI) anchored molecule, but can also occur as a soluble form. The iron-binding properties of melanotransferrin, the tumour-associated antigen p97, have been investigated by many aspects and the results show that, in contrast to other transferrins, melanotransferrin binds only one Fe3+ ion per molecule. The binding properties of its N-terminal site are similar to other transferrins, but its C-terminal site does not bind iron at all. The differences can be related to specific amino acid changes in the C-terminal site. In clinical, The protein melanotransferrin (MTf) is associated with the brain lesions of Alzheimer's disease (AD) and is a potential marker of the disorder. Serum MTf is a candidate marker of AD, even in the early stage when clinical diagnosis is most uncertain.

References

1. Richardson DR. 2000, Eur J Biochem. 267 (5): 1290-8.
2. Kim DK. et al., 2001, Neuropsychopharmacology. 25 (1): 84-90.
3. Rothenberger S. et al., 1996, Brain Res. 712 (1): 117-21.
4. Baker EN. et al., 1992, FEBS Lett. 298 (2-3): 215-8.

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