Mouse IL-18 Protein (Native)

Produkt-Information von IL18 Protein

QC Testing von IL18 Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: IL18 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Asn 36
Molecular Mass	The recombinant mouse IL18 consists of  158 amino acids and predicts a molecular mass of 18.2 KDa. It migrates as an approximately 19 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL18 Protein

Verwandte Produkte & Themen von IL18 Protein

Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>IL-18/IL18

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-1 superfamily and IL-1R/TLR family>>IL-18/IL18

Beschreibung von IL18 Protein

Interleukin-18, also known as Interferon gamma-inducing factor, Iboctadekin, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma IL1F4 and IL18, is a secreted protein which belongs to the IL-1 family. IL-18 / Interleukin-18 is related to the IL1 family by structure, receptors, signalling molecules, and function. IL18 induces gene expression and synthesis of tumour necrosis factor (TNF), IL1, Fas ligand, several chemokines, and vascular adhesion molecules. Similar to IL-1beta, IL-18 / Interleukin-18 is synthesised as a biologically inactive precursor molecule lacking a signal peptide. IL-18 / Interleukin-18 augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I  cells. Rheumatoid arthritis (RA) is a complex autoimmune disease with a strong genetic contribution to its pathogenesis. Interleukin-18 (IL-18) is a proinflammatory cytokine involved in the pathogenesis of RA. IL-18 / Interleukin-18 is also a proinflammatory cytokine whose levels are increased in the subclinical stage of insulin-dependent (type I) diabetes mellitus.

References

1. Dinarello,C.A. 2001,  Ann Rheum Dis. 60 Suppl 3 :iii18-24.
2. Liew,F.Y. et al., 2002, Ann Rheum Dis. 61 Suppl 2 :ii100-2.
3. Martin,R.J. et al., 2005, Genes Immun. 6 (2):171-4.
4. Sakai, K. et al., 2008, J Infect Dis. 197 (12):1752-61.
5. Pawlik, A. et al., 2009, Scand J Rheumatol. 38 (3):159-65.

Sino Biological Inc. liefert Mouse IL-18 Protein (Native) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Mouse IL-18 Protein (Native) lesen Sie bitte: http://www.sinobiological.com/IL-18-Protein-g-9539.html