Mouse CXADR / CAR Protein

14.05.2013

Sino Biological Inc. liefert Mouse CXADR / CAR Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Mouse CXADR / CAR Protein lesen Sie bitte: http://www.sinobiological.com/CXADR-Protein-a-562.html

Produkt-Information von CXADR / CAR Protein

Synonym	CXADR
Protein Construction	A DNA sequence encoding the mouse CXADR (NP_001020363.1) (Met 1-Gly 237) was expressed with six amino acids (ENLYFQ) at the C- terminus.
Source	Mouse
Expression Host	Human Cells

QC Testing von CXADR / CAR Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: CXADR protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Leu 20
Molecular Mass	The recombinant mouse CXADR consists of 225 amino acids and has a calculated molecular mass of 25 kDa. The recombinant protein migrates as an approximately 30 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von CXADR / CAR Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von CXADR / CAR Protein

CXADR (coxsackie virus and adenovirus receptor), also known as CAR, is a 46 kDa type I transmembrane glycoprotein expressed on the basolateral surface, and belongs to the CTX family of the Ig superfamily. It is a receptor for group B coxsackieviruses and subgroup C adenoviruses and also acts as a homophilic adhesion molecule within junctional complexes, notably between epithelial cells lining body cavities and within myocardial intercalated discs. CXADR structrually comprises two extracellular immunoglobulin domains, a transmembrane helix and a C-terminal intracellular domain. The N-terminal Ig domain (D1) of CXADR is necessary and sufficient for adenovirus binding. The C-terminus interacts with several cytoplasmic junctional proteins, microtubules and the actin cytoskeleton. Pairs of transmembrane domains of CXADR associate with each other in a detergent cloud that mimics a cellular plasma membrane. Variants of CXADR are attached to the cell membrane by a GPI- anchor.

References

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