MMP3 / MMP-3 Protein Price Inquiry ( Available Sizes )
- 50μg: Inquiring Price;
- 200μg: Inquiring Price;
- ≥1mg Bulk: Inquiring Price
Produkt-Information von MMP3 / MMP-3 Protein
| Synonym : | CHDS6, MMP-3, SL-1, STMY, STMY1, STR1 |
| Protein Construction: | A DNA sequence encoding the human MMP3 (AAA36321.1) N-terminal fragment (Tyr 18-Thr 272) was expressed and purified. |
| Source: | Human |
| Expression Host: | E.coli |
MMP3 / MMP-3 Protein QC Testing
| Purity: | > 97% as determined by SDS-PAGE. | SDS-PAGE:
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MMP3 / MMP-3 protein |
| Bio-activity: | Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2, AnaSpec, Catalog # 27114. The specific activity is >300 pmoles/min/μg. |
| Endotoxin: | Please contact us for more information. |
| Stability: | Samples are stable for up to twelve months from date of receipt at -70℃ |
| Predicted N terminal: | Met 1 |
| Molecular Mass: | The recombinant human MMP3 consisting of 256 amino acids and has a calculated molecular mass of 29 KDa. It migrates as an approximately 34 KDa band in SDS-PAGE under reducing conditions. |
| Formulation: | Supplied as a 0.2μm filtered solution of 50mM Tris, 10mM CaCL2, 1uM ZnCL2, 50mM NaCL, 0.5% Brij35, PH7.0 - Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
- Please contact us for any concerns or special requirements.
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MMP3 / MMP-3 Protein Usage Guide
| Storage: | Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution: | A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. |
MMP3 / MMP-3 Protein Related Products & Topics
Related Areas:
Proteins:
Antibodies:
Beschreibung von MMP3 / MMP-3 Protein
Matrix metallopeptidase 3 (abbreviated as MMP3), is also known as stromelysin 1 and progelatinase. MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. As a secreted zinc-dependent endopeptidase, MMP3 exerts its functions mainly in extracellular matrix. This protein is activated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMP3 plays a central role in degrading collagen typesⅡ, Ⅲ, Ⅳ, Ⅸ, and Ⅹ, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP3 can also active other MMPs such as MMP1, MMP7, and MMP9, rendering MMP3 crucial in connective tissue remodeling. This protein is considered to be involved in wound repair, progression of atherosclerosis, and tumor initiation. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.
References
- Sternlicht MD. et al., 1999, Cell. 98 (2): 137-46.
- Yoon S. et al., 1999, Res Commun. 265 (2): 563-8.
- Biondi ML. et al., 2000, Clin Chem. 46 (12): 2023-4.
Sino Biological Inc. bietet MMP3 / MMP-3 Protein mit höherer Quatität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.
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