MMP-2 Antikörper

03.08.2012

Produkt-Information von MMP-2 Antikörper

Immunogen	Recombinant Human MMP-2 protein (Catalog#10082-HNAH)
Antibody Type	Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
Clone ID	026
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was obtained from a rabbit immunized with purified, recombinant Human MMP-2 (rh MMP-2; Catalog#10082-HNAH; NP_004521.1; Met 1-Cys660).

Usage Guide von MMP-2 Antikörper

Specificity	Human MMP-2
	No cross-reactivity in ELISA with Human MMP1 Human MMP9 Human MMP8
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human MMP2 in WB. Using a DAB detection system, the detection limit for Human MMP2 is approximately 10 ng/lane under non-reducing conditions and 5 ng/lane under reducing conditions.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Hintergrund von MMP-2 Antikörper

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases and tumor invasion. 72 kDa type IV collagenase, also known as Matrix metalloproteinase-2, Gelatinase A, MMP-2, and CLG4A, is a secreted protein which belongs to thepeptidase M10A family. MMP-2/MMP2 contains threefibronectin type-II domains and four hemopexin-like domains. MMP-2/MMP2 is ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, atherosclerotic plaque rupture, as well as degrading extracellular matrix proteins. MMP-2/MMP2 can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. MMP-2/MMP2 cleaves KISS at a Gly-|-Leu bond and appears to have a role in myocardial cell death pathways. MMP-2/MMP2 contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Defects in MMP-2/MMP2 are the cause of Torg-Winchester syndrome (TWS), also known as multicentric osteolysis nodulosis and arthropathy (MONA). TWS is an autosomal recessive osteolysis syndrome. It is severe with generalized osteolysis and osteopenia.

References

Brooks P.C. et al., 1998, Cell 92: 391-400.
Fernandez-Patron C. et al., 1999, Circ. Res. 85: 906-11.
Fernandez-Patron C. et al., 2000, Circ. Res. 87: 670-6.
Bello L., et al., 2001, Cancer Res. 61: 8730-6.
Kandasamy A.D. et al., 2009, Cardiovasc. Res. 83: 698-706.

Sino Biological Inc. liefert MMP-2 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über MMP-2 Antikörper lesen Sie bitte: http:www.sinobiological.com/MMP-2-Antibody-g-9200.html

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
MMP-2/MMP2	Human	MMP-2/MMP2 Protein, Recombinant, with Native	10082-HNAH

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human MMP-2/MMP2	WB, ELISA	MMP-2 Antibody	10082-MM05
Human MMP-2/MMP2	WB, ELISA	MMP-2/MMP2 Antibody, Rabbit PAb	10082-RP01
Human MMP-2/MMP2	WB, ELISA	MMP-2/MMP2 Antibody, Rabbit PAb (Antigen Affinity Purified)	10082-RP02
Human MMP-2/MMP2	WB	MMP-2 Antibody	10082-R026
Human MMP-2/MMP2	ELISA	MMP-2 Antibody	10082-R029

MMP-2 Antikörper

Produkt-Information von MMP-2 Antikörper

Usage Guide von MMP-2 Antikörper

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Hintergrund von MMP-2 Antikörper

References