Ly108 / SLAMF6 Antikörper

03.03.2012

Produkt-Information von Ly108 / SLAMF6 Antikörper

Immunogen	Recombinant Mouse Ly108 / SLAMF6 protein (Catalog#50275-M08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse Ly108 / SLAMF6 (rM Ly108 / SLAMF6; Catalog#50275-M08H; NP_109635.1; Met 1-Asn 239). Total IgG was purified by Protein A affinity chromatography.

Ly108 / SLAMF6 Antikörper Usage Guide

Specificity	Mouse Ly108 / SLAMF6
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse SLAMF6 in WB.
Direct ELISA	This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse SLAMF6. The detection limit for Mouse SLAMF6 is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von Ly108 / SLAMF6 Antikörper

SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly108, is a single-pass type I membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly108 contains oneIg-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly108 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly108 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SpD1A/SAP. SLAMF6 / Ly108 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SpD1A) as well as with Sp domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly108 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

References

Gray CW, et al., 2000, Eur. J. Biochem.267 (18): 5699-710.
Bottino C, et al., 2001,J Exp Med. 194 (3): 235-46.
Valdez PA, et al., 2004,J. Biol. Chem.279 (18): 18662-9.
Claus M, et al., 2007, Front. Biosci.13: 956-65.

Sino Biological Inc. liefert Ly108 / SLAMF6 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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