LRP10 Protein (His Tag)

Produkt-Information von LRP10 Protein

QC Testing von LRP10 Protein

Purity	> 97 % as determined by SDS-PAGE	SDS-PAGE: LRP10 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His 17
Molecular Mass	The secreted recombinant human LRP10 consists of 435 amino acids and has a predicted molecular mass of 47.5 kDa. The apparent molecular mass of rhLRP10 is approximately 60 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von LRP10 Protein

Verwandte Produkte & Themen von LRP10 Protein

Cardiovascular>>Lipid Metabolism>> LRP10

Beschreibung von LRP10 Protein

Low-density lipoprotein receptor-related protein 10 (LRP10) is one member of the Low-density lipoprotein receptor-related protein family. LRP10 plays an important role in lipoprotein metabolism. Chylomicron remnants, produced by lipolysis, are rapidly taken up by the liver via an apolipoprotein E (apoE)-mediated, receptor-dependent process. The low density lipoprotein (LDL) receptor-related protein (LRP) has been suggested as the potential apoE receptor. low density lipoprotein (LDL) receptor-related protein (LRP) 10 (LRP10) inhibits the canonical Wnt / beta- catenin signaling pathway. The beta-catenin/T cell factor (TCF) transcriptional activity in HEK293 cells was activated by transfection with Wnt3a or LRP6, which was then inhibited by co-transfection with LRP10. Deletion of the extracellular domain of LRP10 negated its inhibitory effect. It sugested that LRP10 may interfere with the formation of the beta-catenin/TCF complex and its binding to target DNA in the nucleus, and that the extracellular domain of LRP10 is critical for inhibition of the canonical Wnt/beta-catenin signaling pathway. LRP10 has been improved to play a significant role in the brain physiology other than lipoprotein metabolism.

References

1. Jeong YH. et al., 2010, Biochem Biophys Res Commun. 392 (4): 495-9.
2. Beisiegel U. et al., 1991, Proc Natl Acad Sci. 88 (19): 8342-6.
3. Strickland DK. et al., 1990, J Biol Chem. 265 (29): 17401-4.

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