Leukotriene A4 Hydrolase / LTA4H Antikörper

08.11.2012

Sino Biological Inc. liefert Leukotriene A4 Hydrolase / LTA4H Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Leukotriene A4 Hydrolase / LTA4H Antikörper lesen Sie bitte: http://www.sinobiological.com/Leukotriene-A4-Hydrolase-LTA4H-Antibody-g-10106.html

Produkt-Information von Leukotriene A4 Hydrolase / LTA4H Antikörper

Immunogen	Recombinant Human Leukotriene A4 Hydrolase / LTA4H protein (Catalog#10276-H08B)
Antibody Type	Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
Clone ID	455
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was obtained from a rabbit immunized with purified, recombinant Human Leukotriene A4 Hydrolase / LTA4H (rh Leukotriene A4 Hydrolase / LTA4H; Catalog#10276-H08B; NP_000886.1; Met 1-Asp 611).

Usage Guide von Leukotriene A4 Hydrolase / LTA4H Antikörper

Specificity	Human Leukotriene A4 Hydrolase / LTA4H
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human LTA4H. The detection limit for Human LTA4H is approximately 0.0049 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Related Areas:

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>Leukotriene A4 Hydrolase/LTA4H

Enzyme>>Lipid Metabolism Enzymes>>Leukotriene A4 Hydrolase/LTA4H

Cardiovascular>>Lipid Metabolism>>Lipid Metabolism Enzymes>>Leukotriene A4 Hydrolase/LTA4H

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
Leukotriene A4 Hydrolase/LTA4H	Human	Leukotriene A4 Hydrolase/LTA4H Protein, Recombinant	10276-H08B
Leukotriene A4 Hydrolase/LTA4H	Mouse	Leukotriene A4 Hydrolase/LTA4H Protein, Recombinant	50268-M08B

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human Leukotriene A4 Hydrolase/LTA4H	WB, ELISA	Leukotriene A4 Hydrolase/LTA4H Antibody, Rabbit PAb (Antigen Affinity Purified)	10276-RP02
Human Leukotriene A4 Hydrolase/LTA4H	WB, ELISA	Leukotriene A4 Hydrolase / LTA4H Antibody	10276-R201
Human Leukotriene A4 Hydrolase/LTA4H	ELISA	Leukotriene A4 Hydrolase / LTA4H Antibody	10276-R455
Human Leukotriene A4 Hydrolase/LTA4H	ELISA	Leukotriene A4 Hydrolase / LTA4H Antibody	10276-R457
Mouse Leukotriene A4 Hydrolase/LTA4H	WB, ELISA	Leukotriene A4 Hydrolase/LTA4H Antibody, Rabbit PAb	50268-RP01
Mouse Leukotriene A4 Hydrolase/LTA4H	WB, ELISA	Leukotriene A4 Hydrolase/LTA4H Antibody, Rabbit PAb (Antigen Affinity Purified)	50268-RP02

Hintergrund von Leukotriene A4 Hydrolase / LTA4H Antikörper

The leukotrienes (LTs) are a class of structurally related lipid mediators involved in the development and maintenance of inflammatory and allergic reactions. In the biosynthesis of LTs, arachidonic acid was converted into the unstable intermediate epoxide LTA4, which may in turn be conjugated with glutathione to form the spasmogenic LTC4, or hydrolyzed into the proinflammatory lipid mediator LTB4 in a reaction catalyzed by Leukotriene A4 hydrolase (LTA4H). LTB4 is a classical chemoattractant of human neutrophils and triggers adherence and aggregation of leukocytes to vascular endothelium, and also modulates immune responses. As a bifunctional zinc metalloenzyme, LTA4H also exhibits an anion-dependant arginyl aminopeptidase activity of high efficiency and specificity in addition to its epoxide hydrolase activity. LTA4H is thus regarded as a therapeutic target for inflammation.

References

Mancini, J.A. and Evans. J.F. 1995, Eur. J. Biochem. 231: 65-71.
Orning, L. et al., 1994, J. Biol. Chem. 269: 11269-11273.
Rudberg, P.C. et al., 2004, J. Biol. Chem. 279: 27376-27382.
Qiu, H. et al., 2006, Proc. Natl. Acad. Sci. USA. 103: 8161-8166.