KIRREL3 / NEPH2 Antikörper (Antigen Affinität reinigt)

12.03.2012

Produkt-Information von KIRREL3 / NEPH2 Antikörper

Immunogen	Recombinant Mouse KIRREL3 / NEPH2 protein (Catalog#50339-M08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse KIRREL3 / NEPH2 (rM KIRREL3 / NEPH2; Catalog#50339-M08H; Q8BR86-1; Met 1-Ala 535). KIRREL3 / NEPH2 specific IgG was purified by Mouse KIRREL3 / NEPH2 affinity chromatography.

KIRREL3 / NEPH2 Antikörper Usage Guide

Specificity	Mouse KIRREL3 / NEPH2
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse KIRREL3 in WB. Using a DAB detection system, the detection limit for Mouse KIRREL3 is approximately 2 ng/lane under non-reducing conditions and 0.5 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse KIRREL3. The detection limit for Mouse KIRREL3 is approximately 0.039 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von KIRREL3 / NEPH2 Antikörper

Kin of IRRE-like protein 3, also known as Kin of irregular chiasm-like protein 3, Nephrin-like protein 2 and KIRREL3, is a single-pass type I membrane protein which belongs to theimmunoglobulin superfamily. KIRREL3 contains fiveIg-like C2-type (immunoglobulin-like) domains. KIRREL3 is expressed in fetal and adult brain. It is also expressed in kidney, specifically in podocytes of kidney glomeruli. KIRREL3 could be involved in the hematopoetic supportive capacity of stroma cells. KIRREL3 might play a role in the axonal pathfinding, cell recognition, and synapse formation of DRG neurons on appropriate target cells, including the targeting of proprioceptive neurons on muscle spindles through the interaction with nephrin. Defects in KIRREL3 are the cause of mental retardation autosomal dominant type 4 (MRD4) which is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.

References

Sellin L., et al., 2003, FASEB J. 17:115-117.
Komori,T. et al., 2008, J Comp Neurol. 511 (1): 92-108.
Bhalla K., et al., 2008, Am. J. Hum. Genet. 83: 703-713.

Sino Biological Inc. liefert KIRREL3 / NEPH2 Antikörper (Antigen Affinität reinigt) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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