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| Immunogen | Recombinant Human ISG15 protein (Catalog#12729-HNAE) |
| Antibody Type | Rabbit Polyclonal Antibody ( Antibody Purification Platform ) |
| Ig Type | Rabbit IgG |
| Formulation | 0.2 μm filtered solution in PBS with 5% trehalose |
| Preparation | Produced in rabbits immunized with purified, recombinant Human ISG15 (rh ISG15; Catalog#12729-HNAE; AAH09507.1; Met 1-Ser 165). ISG15 specific IgG was purified by Human ISG15 affinity chromatography. |
| Specificity | Human ISG15 |
| Western blot | This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect pro form of Human ISG15 in WB. Using a DAB detection system, the detection limit for pro form of Human ISG15 is approximately 1 ng/lane under non-reducing conditions and 1 ng/lane under reducing conditions. |
| Direct ELISA | This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect pro form of Human ISG15. The detection limit for pro form of Human ISG15 is approximately 0.039 ng/well. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
Neuroscience>>Neurodegenerative Disease>>Ubiquitin-proteasome pathway>>ISG15
Enzyme>>Protein Kinase>>Intracellular Kinase>> Jak (Janus Kinase) >>ISG15
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| ISG15 | Human | G1P2 / ISG15 (mature form) Protein, Recombinant, Native | 12729-HNAE1 |
| ISG15 | Human | ISG15 / G1P2 Protein, Recombinant, Native | 12729-HNAE |
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human ISG15 | WB, ELISA | ISG15 Antibody (Antigen Affinity Purified) | 12729-RP02 |
Ubiquitin-like protein ISG15, also known as Interferon-induced 15 kDa protein, Interferon-induced 17 kDa protein, Ubiquitin cross-reactive protein, ISG15 and G1P2, is a cytoplasm and secreted protein which is detected in lymphoid cells, striated and smooth muscle, several epithelia and neurons. ISG15 / G1P2 contains 2 ubiquitin-like domains. ISG15 / G1P2 is a ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. ISG15 / G1P2 enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 / G1P2 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. ISG15 / G1P2 Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. ISG15 / G1P2 is deconjugated by USP18/UBP43. It shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. ISG15 / G1P2 may serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. ISG15 / G1P2 may also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. ISG15 / G1P2 seems to display antiviral activity during viral infections.
Sino Biological Inc. liefert ISG15 Antikörper (Antigen Affinity Purified) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.
Weitere Informationen über ISG15 Antikörper (Antigen Affinity Purified) lesen Sie bitte: http:www.sinobiological.com/ISG15-Antibody-g-9257.html
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