IL36B / IL1F8 Protein (His Tag)

30.05.2012

Produkt-Information von IL36B / IL1F8 Protein

Synonym	IL36B, IL1F8, IL1H2, IL1F8
Protein Construction	A DNA sequence encoding the mature form of human IL1F8 (NP_775270.1) (Lys 5- Glu 157) was expressed with a polyhistide tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von IL36B / IL1F8 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: IL36B / IL1F8 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human IL1F8 consists of 169 amino acids and predicts a molecular mass of 19.3 KDa. It migrates as an approximately 20 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL36B / IL1F8 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von IL36B / IL1F8 Protein

Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contains a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines includ four members, with three having pro-inflammatory effects such as IL1F8 and the fourth member being an IL-1 receptor antagonist (IL-1Ra). IL-1 family members exert their effects through binding to receptors that belong to the IL-1 receptor (IL-1R) family. IL1F8 exerts proinflammatory effects in primary human joint cells. Joint and serum IL-1F8 protein levels did not correlate with inflammation, but they were high in some human serum samples tested, including samples from patients with rheumatoid arthritis. IL1F8 also activated NK-κB.

References

Magne D, et al., 2006, Arthritis Research & Therapy. 8: R80.
Smith DE. et al., 2000, The Journal of Biological Chemistry. 275: 1169-75.

Sino Biological Inc. liefert IL36B / IL1F8 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über IL36B / IL1F8 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/IL36B-IL1F8-Protein-g-9060.html