IL1F6 / IL36A Antikörper

15.08.2012

Produkt-Information von IL1F6 / IL36A Antikörper

Immunogen	Recombinant Human IL1F6 / IL36A protein (Catalog#10607-HNAE)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Human IL1F6 / IL36A (rh IL1F6 / IL36A; Catalog#10607-HNAE; Q9UHA7; Met 1-Phe 158). Total IgG was purified by Protein A affinity chromatography.

Usage Guide von IL1F6 / IL36A Antikörper

Specificity	Human IL1F6 / IL36A
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human IL1F6 in WB. Using a DAB detection system, the detection limit for Human IL1F6 is approximately 1 ng/lane under non-reducing conditions and 2 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human IL1F6. The detection limit for Human IL1F6 is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von IL1F6 / IL36A Antikörper

Related Areas:

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-1 superfamily and IL-1R/TLR family>>IL-1F6/IL1F6

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-1F6/IL1F6	Human	IL1F6 / IL36A Protein, Recombinant, Native	10607-HNAE
IL-1F6/IL1F6	Human	IL1F6 / IL36A Protein, Recombinant	10607-H07E1
IL-1F6/IL1F6	Human	IL1F6 / IL36 (aa 6-158) Protein, Recombinant	10607-HNCE1
IL-1F6/IL1F6	Mouse	IL-1F6/IL-1 epsilon Protein, Recombinant, Native	50095-HNAE

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human IL-1F6/IL1F6	WB, ELISA	IL1F6 / IL36A Antibody	10607-RP01
Mouse IL-1F6/IL1F6	WB, ELISA	IL-1F6 Antibody (Antigen Affinity Purified)	50095-RP02

Hintergrund von IL1F6 / IL36A Antikörper

Interleukin-1 family member 6, also known as IL-1F6, FIL1 epsilon, Interleukin-1 epsilon, IL-1 epsilon, IL1F6 and FIL1E, is a secreted protein which belongs to the IL-1 family. IL-1F6 is a new IL-1 family member. IL1F6 / FIL1E is expressed in immune system, fetal brain and adipose tissue and that IL-1F6 and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly, IL-1F6 inhibits PPARγ expression which may lead to reduced adipocyte differentiation suggesting metabolic effects of this cytokine.. IL1F6 / FIL1E, along with IL-36β / IL-1F8 and IL-36γ / IL-1F9, has been shown to act as an agonist by activating the pathway involving NF-κB and MAPK in an IL-1 Rrp2 dependent manner. IL1F6 / FIL1E may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex.

References

Smith DE. et al., 2000, J Biol Chem. 275:1169-1175.
Dunn E. et al. 2001, Trends Immunol. 22-53.
Nicklin MJ. et al., 2002, Genomics. 79 (5): 718-25.
Blumberg H. et al., 2007, J Exp Med. 204 (11): 2603-14.
Dinarello C. et al., 2010, Nat Immunol. 11: 973.

Sino Biological Inc. liefert IL1F6 / IL36A Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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